The strategy of combined site directed mutagenesis and chemical modification creates chemically modified mutants (CMMs) with greatly broadened substrate specificities. We have previously reported that the CMMs of subtilisin Bacillus lentus (SBL) are efficient catalysts for the coupling of both Land D-amino acids. We now report that these powerful catalysts also allow amide bond formation betwee...

The evolution of biomedical technology has led to enhanced use of medical devices in healthcare delivery. Clinical Engineering Departments (CEDs), in order to improve their services and monitor the outcomes, are introducing more and more telematic means. In the present work, a new computerized, integrated, windows oriented system intended for CED management is proposed. The system model is base...

Maintenance can play a key role in the long-term profitability of a company in the manufacturing sector, where it can have major impact on delivery, quality and cost. The importance of maintenance has increased, as high productivity and quality can be achieved by means of well-developed and organized maintenance strategies. However, this assumes that maintenance is controlled in such a way that...

A major portion of patient care planning occurs during the process of writing orders. Computerized order entry can present collections of predefined orders to the user during the ordering process. These order sets are useful for promoting standards of care, and provide one element of structured clinical knowledge to be used by Computerized Provider Order Entry (CPOE) systems at the point of car...

Medical devices developed for human application are used for diagnostic or treatment purposes. They may either be an instrument, an apparatus or a material. Moreover, these devices can be used for daily patient care as well as for medical scientific purposes. Risk management involves the identification, understanding, control, and prevention of failures when the medical devices are connected to...

This paper presents a new bridge management system (J-BMS). It is integrated with a concrete bridge rating expert system that can be used to evaluate the serviceability of existing concrete bridges. The proposed J-BMS not only evaluates the performance of bridges, but also offers a rehabilitation strategy based on a combination of maintenance cost minimization and quality maximization. In this ...