The peptide hormones guanylin and uroguanylin are ligands of the intestinal guanylyl cyclase-C (GC-C) that is involved in the regulation of epithelial water and electrolyte transport. The small peptides contain 15 and 16 amino acids, respectively, and two disulfide bonds with a 1-3/2-4 connectivity. This structural feature causes the unique existence of two topological isoforms for each peptide...

Recently, Cho et al. [Y. J. Cho, R. Saadati, S. H. Wang, Common xed point theorems on generalized distance in ordered cone metric spaces, Comput. Math. Appl. 61 (2011) 1254-1260] dened the concept of the c-distance in a cone metric space and proved some xed point theorems on c-distance. In this paper, we prove some new xed point and common xed point theorems by using the distance in ordered con...

ultimate limits of an open pit, which define its size and shape at the end of the mine’s life, is the pit with the highest profit value. a number of algorithms such as floating or moving cone method, floating cone method ii and the corrected forms of this method, the korobov algorithm and the corrected form of this method, dynamic programming and the lerchs and grossmann algorithm based on grap...

In this paper the characteristics of unsteady three-dimensional incompressible flows with heat transfer are obtained along with artificial compressibility of Chorin. At first, compatibility equations and pseudo characteristics for three-dimensional flows are derived from five governing equations (continuity equation, Momentum equations in three directions, and energy equation) and then results ...

Folate analogs that inhibit dihydrofolate reductase result in only partial interconversion of tetrahydrofolate cofactors to dihydrofolate with preservation of the major portion of reduced cellular folate cofactors in L1210 leukemia cells. One possible explanation for this phenomenon is that low levels of dihydrofolate polyglutamates that accumulate in the presence of antifolates block thymidyla...

Let $X$ be a  Banach  space, $Csubset X$  be  a  closed  convex  set  included  in  a well-based cone $K$, and also let $sigma_C$ be the support function which is defined on $C$. In this note, we first study the existence of a  bounded base for the cone $K$, then using the obtained results, we find some geometric conditions for the set  $C$,  so that ${mathop{rm int}}(mathrm{dom} sigma_C) neqem...

Huang and Zhang cite{Huang} have introduced the concept of cone metric space where the set of real numbers is replaced by an ordered Banach space. Shojaei cite{shojaei} has obtained points of coincidence and common fixed points for s-Contraction mappings which satisfy generalized contractive type conditions in a complete cone metric space.In this paper, the notion of complete cone metric ...