dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. in this study, antihypertensive effects of 5 newly synthesized derivatives of dhp was examined the in rat model of two-kidney, one-clip renal hypertension. the results showed that those compounds containing two nitroxy groups had less decreasing effect on map (men arterial...

The relationship between protein mutations and conformational change can potentially decipher the language relating sequence to structure. Elsewhere, we presented the Protein Mutant Resource (PMR), an online tool that systematically identified related mutants in the Protein DataBank (PDB), inferred mutant Gene Ontology classifications using data-mining, and allowed intuitive exploration of rela...