OBJECTIVE This study ascertained the incidence of complications during pregnancy, labor, and delivery and the neonatal characteristics of infants born to women with schizophrenia, bipolar disorder, or major depression in a population-based cohort. METHOD Based on records linkage across a psychiatric case register and prospectively recorded obstetric data, the study comprised women with schizo...

Zika virus (ZIKV) is a mosquito-borne arbovirus from the family Flaviviridae, which had caused some epidemics since its discovery in 1947 without any significant impacts on public health. In 2015, however, a 20-fold increase in congenital microcephaly cases in northeastern Brazil was attributed to prenatally acquired ZIKV infection. Traditionally, TORCH agents have 4 common characteristics incl...

Congenital transmission of tuberculosis is rare. In the past the diagnosis has usually been made in the post-mortem room and the condition has interested the pathologist more than the clinician. In the majority of published cases the nature of the illness has been apparent soon after birth. In others, however, the symptoms have not appeared for several weeks or months and it is not easy to acce...

A congenital malformation (CM) is a congenital structural defect that often occurs in the first trimester. Although significant progress has been made in identifying the etiology of some birth defects, approximately 65% have no known or identifiable cause [1-3]. For 20-25% of anomalies there seems to be a "multifactorial" cause, involving a complex interaction of multiple minor genetic anomalie...

It is widely held amongst paediatric surgeons that babies born with major congenital abnormalities remain srnall even after successful surgical treatment. Forshall (1960) showed that many children with certain deformities achieve normal weight after correction; but no systematic study of the pattern of their long-term development appears to have been carried out. The purpose of this investigati...

DYT1 early-onset primary dystonia (DYT1) is a well-described dystonia caused by an in-frame GAG nucleotide deletion in the TOR1A gene, c.907_909delGAG. The only phenotype linked to TOR1A is dystonia. Homozygous GAG deletions or compound heterozygosity for mutations in TOR1A have never been reported in humans. Arthrogryposis, defined as multiple congenital contractures, affects 1 in 3,000–5,000 ...

Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including micr...

BACKGROUND Emergency department workup of pediatric fever typically focuses on ruling out serious bacterial infection, but other disease processes can cause fever. Congenital leukemia is a rare but important cause of fever in neonates. We review the presentation, pathophysiology, and potential complications of congenital leukemia presenting to the emergency department as pediatric fever. CASE...

OBJECTIVES To describe the inpatient length of stay and related charges for adults in the United States with childhood-onset chronic disease and to examine patterns with respect to different hospital settings. DESIGN We analyzed data from the 2002 Nationwide Inpatient Sample, a nationally representative data set of hospital discharges. We performed a case-mix-adjusted, sample-weighted regress...

Although the incidence of congenital heart disease (CHD) is similar worldwide, the burden of supporting these patients falls more heavily on countries with high fertility rates. In a country with a fertility rate of about eight per woman, the population has to support four times as many children with CHD as in a country with a fertility rate of two. Countries with the highest fertility rates te...