نتایج جستجو برای: conjugation
تعداد نتایج: 13523 فیلتر نتایج به سال:
Substantial quantities of 2,6-dichloroindophenol are bound to mitochondrial constituents. It is likely that binding is mediated by conjugation of dye to thiol groups, since reaction conditions favoring binding are completely analogous to conditions favorable for the conjugation of dye to isolated thiol compounds. Thus, procedures which promote the maintenance of reduced 2,6-dichloroindophenol (...
Introduction: The bacterial Asparaginase is used in the treatment of asparagine-dependent tumors, particularly lymphatic sarcoma and acute lymphoblastic leukemia. However, the instability of the enzyme increases the number of injections that are accompanied by high immune responses. The aim of this study was to investigate the conjugation of L-asparaginase with nanochitosan glutaraldehyde (NCG)...
Campylobacter jejuni, the leading bacterial cause of human gastroenteritis in the United States, displays significant strain diversity due to horizontal gene transfer. Conjugation is an important horizontal gene transfer mechanism contributing to the evolution of bacterial pathogenesis and antimicrobial resistance. It has been observed that heat shock could increase transformation efficiency in...
It is becoming increasingly clear that site-specific conjugation offers significant advantages over conventional conjugation chemistries used to make antibody-drug conjugates (ADCs). Site-specific payload placement allows for control over both the drug-to-antibody ratio (DAR) and the conjugation site, both of which play an important role in governing the pharmacokinetics (PK), disposition, and ...
Ubiquitin(Ub) like proteins (Ubls) are conjugated to their targets by an enzymatic cascade involving an E1 activating enzyme, an E2 conjugating enzyme, and in some cases an E3 ligase. ISG15 is a Ubl that is conjugated to cellular proteins after IFNstimulation. Although the E1 enzyme for ISG15 (Ube1L E1ISG15) has been identified, the identities of the downstream components of the ISG15 conjugati...
In recent years, several oconjugation protocols have been developed to improve the functional properties of the enzyme lysozyme. In this study, the optimum conditions of lysozyme – oxidized inulin conjugation and functional properties of the modified lysozyme were investigated. Initially, inulin (MW about 25 kDa) was oxidized by periodate to provide the reactive carbonyl groups to attach to am...
Cells of opposite mating type, &x and a2, of the anther smut, Ustilago violacea assemble a conjugation tube after about 3-4 h of mating on nutrient-free media. Low doses of ultraviolet light (u.v.) delay but do not prevent conjugation in wild-type strains if given in the first 2-3 h of mating. However, irradiation later than this period has little effect and conjugation proceeds normally. The u...
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