RESULTS. Compared with the control, increased accumulations of type I and type III collagens were detected by immunohistochemistry in fibrotic conjunctiva of patients with OCP. Weak and sparse expression of HSP47 was detected in the epithelial cells and stromal fibroblasts in control conjunctival tissues. In contrast to the control, the expression of HSP47 was markedly increased in the stromal ...

AIM To investigate the expression and function of interleukin-4 receptor alpha (IL-4Ralpha) in human conjunctival epithelial cells (HCjECs). METHODS The presence of IL-4Ralpha mRNA and protein was examined by reverse transcription (RT) PCR and immunohistology, respectively. Cell surface expression was examined by flow cytometry. The effects of interleukin (IL)-4 or IL-13 on the tyrosine phosp...

OBJECTIVE To determine the effect of a topical antagonist to the chemokine receptor 2 (CCR2) in a murine model of dry eye disease. METHODS The effects of a topical CCR2 antagonist and a vehicle control treatment were studied in murine dry eyes. A controlled environment chamber induced dry eye by exposing mice to high-flow desiccated air. Corneal fluorescein staining and enumeration of corneal...

AIM To compare the conjunctival and corneal reactions of commercially available solution of latanoprost (Xalatan) and preservative-free (PF) tafluprost in rabbits. METHODS The rabbits received 50 microl of phosphate-buffered saline (PBS), PF-tafluprost 0.0015%, latanoprost 0.005% or benzalkonium chloride (BAK) 0.02%; all solutions were applied at 5 min intervals for a total of 15 times. The o...

OBJECTIVE To study the efficacy of topical application of alpha-linolenic acid (ALA) and linoleic acid (LA) for dry eye treatment. METHODS Formulations containing ALA, LA, combined ALA and LA, or vehicle alone, were applied to dry eyes induced in mice. Corneal fluorescein staining and the number and maturation of corneal CD11b(+) cells were determined by a masked observer in the different tre...

Immune responses to Chlamydia trachomatis infection in trachoma do not protect against reinfection or the development of scarring and blindness. In addition, the immunoregulatory contribution of cytokines to the development of conjunctival histopathology or protection is undefined. In this study, conjunctival cytokine mRNA transcripts were compared among subgroups of chlamydia infection status ...

purpose: to determine the prevalence of various types of conjunctival lesions, at a tertiary ophthalmic center in fars province, south of iran. methods: histopathologic slides and medical records of conjunctival lesions submitted to the pathology department of khalili hospital, shiraz, iran was reviewed from april, 2009 to july, 2013. the histopathologic diagnoses were categorized into benign, ...

purpose: a 12 year-old boy and a known case of job’s syndrome presented with a large conjunctival mass which represented coexistence of hpv and hsv infections. case report: the presence of hpv virus within these lesions was confirmed by biopsy and dna analysis. the mass lesions did not respond to anti-hpv therapy with topical interferon-α2b, oral cimetidine and oral acyclovir, but improved prom...

purpose : to evaluate the efficiency and safety of using autologous fibrin glue for attachment of a conjunctival autograft in primary pterygium surgery methods : in this prospective interventional case series, 15 eyes from 13 patients with primary nasal pterygium were included for conjunctival autograft surgery. on the operation day, thrombin and fibrinogen were prepared from the patient’s own ...

In our recently published study (1), we describe genetic similarities between conjunctival and cutaneousmelanoma and propose that the treatment rationale for patients with metastasized conjunctival melanoma should be adapted to that for metastasized cutaneous melanoma. Weber and colleagues (2) responded to this, reporting that a BRAF V600E–mutant metastasized conjunctival melanoma patient treat...