Constitutive modeling of clay is an important research in geotechnical engineering. It is difficult to use precise mathematical expressions to approximate stress-strain relationship of clay. Artificial neural network (ANN) and support vector machine (SVM) have been successfully used in constitutive modeling of clay. However, generalization ability of ANN has some limitations, and application of...

The cloned herpes simplex virus type 1 (HSV-1) thymidine kinase (TK; ATP:thymidine 5'-phosphotransferase, EC 2.7.1.21) gene can be used to transform TK- cells to a TK+ phenotype. Transformants generated in this way express TK at a basal constitutive level that is inducible to a higher level by infection with TK- herpes virus. We have studied the effect of mutations generated in vitro on both th...

this paper presents a model for prediction of the mechanical behavior of sand-gravel mixtures using generalized plasticity and critical state concepts. proposed model is based on the difference between critical state lines of sand and sand-gravel mixture in e-lnp' plane. a generalized plasticity model is considered as the base model for sandy soil. its state parameter, dilation rate and ha...

Vascular endothelial growth factor (VEGF) is a key angiogenic molecule that plays an important role in the growth and metastasis of many types of human cancer, including pancreatic adenocarcinoma. In this study, we explored the regulation of VEGF in human pancreatic cancer cells. Over 70% of the human pancreatic cancer cell lines studied in vitro secreted constitutively high levels of VEGF. Hig...

Alternative splicing (AS) is a major engine that drives proteome diversity in mammalian genomes and is a widespread cause of human hereditary diseases. More than 95% of genes in the human genome are alternatively spliced, and the most common type of AS is the cassette exon. Recent discoveries have demonstrated that the cassette exon plays an important role in genetic diseases. To discover the f...

The numerical dimensioning of injection heads and tools for the extrusion of rubber profiles requires both, the experimental investigation and numerical consideration of the viscoelastic material behavior. Usage of finite element software allows drastic reduction of a time-consuming empiric adaptation process for the design of extrusion tools. In this context, viscoelasticity covers three diffe...

Abstract-By using Lee’s (1969. 1. Appf. hfech. 36, l-6) multiplicative decomposition of the deformation gradient into its elastic and plastic part of Hill and Rice’s (1973. SlAbf J. Appf. Math. U, 44S-461) constitutive framework. explicit and consistent constitutive analysis of large clastoplastic deformation is given. Both isotropic and anisotropic material behaviour is considered. so that som...