Over the past 10 years there have been many changes in the details of diabetic management. The development of home monitoring for capillary blood glucose and widespread availability of measurements of glycosylated haemoglobin have provided direct evidence that most diabetic children have poor or very poor glycaemic control. Additionally, there has been further evidence in support of the hypothe...

Acute nicotinic acid (NiAc) administration results in rapid reduction of plasma FFA concentrations. However, sustained NiAc exposure is associated with tolerance development resulting in return of FFA to pretreatment levels. The aim of this study was to determine whether a 12 h rectangular exposure profile (intermittent dose group) could avoid tolerance development and thereby reverse insulin r...

In recent years, there is a surge in the popularity of using insulin pump or continuous subcutaneous insulin infusion (CSII) therapy, as opposed to multiple daily injections (MDI) by insulin syringe or an insulin pen. Some case studies have suggested that insulin delivery failure may be caused by the precipitation of insulin within the infusion set. Speculation also exists that the flow of insu...

to evaluate the effect of intravenous infusion of a soybean based lipid emulsion (lipovenoes 10%) on some blood constituents in sheep, a replicated 2 × 2 latin square design experiment was conducted in four clinically healthy ewes. lipid emulsion (le group) or normal saline (ns group) was infused intravenously at a rate of 0.025 ml kg-1 per min for 6 hr and the concentrations of blood triglycer...

Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described. Hyperglycemic clamp technique. The plasma glucose concentration is acutely raised to 125 mg/dl above basal levels by a priming infusion of glucose. The desired hyperglycemic plateau is subsequently maintained ...

Diabetes therapy is normally based on discrete insulin infusion that uses long-time interval measurements. Nevertheless, in this paper, a continuous drug infusion closed-loop control system was proposed to avoid the traditional discrete approaches by automating diabetes therapy. Based on a continuous insulin injection model, two controllers were designed to deal with this plant. The controllers...

As suboptimal blood glucose control has a lasting harmful effect even if control improves later, intensive insulin therapy to minimise hyperglycaemia is now recommended for all patients with type 1 diabetes. The new rapid- and long-acting insulin analogues offer more physiological insulin profiles than traditional insulin preparations. Continuous insulin infusion ("pump therapy") may provide a ...

background: the effective therapeutic dose of pralidoxime methylsulphate for organophosphate (op) poisoning is necessary to be clarified. this study was designed to comparatively assess the blood level of pralidoxime (bpl) and clinical outcomes in op poisoned patients treated with intermittent dosing and patients treated with continuous infusion. methods: this was a prospective, open labelled, ...

OBJECTIVE To compare the safety and efficacy of insulin aspart (IAsp), buffered regular insulin (BR), and insulin lispro administered by continuous subcutaneous insulin infusion (CSII) in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS After completing a 4-week run-in period with BR, 146 adult patients with type 1 diabetes (with pretrial CSII experience) were randomly assigned (2:2...