Nifedipine is a hypertension drug must be consumed three times a day due to its low oral bioavailability. One way of developing a controlled drug delivery system is making nifedipine microcapsules by using environmentally friendly polymers of polylactic acid and polycaprolactone via the evaporation method using oil-in-water solvents. Polylactic acid and polycaprolactone can be said to be enviro...

hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. the present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on ph-sensitive polymers such as poly (acrylic acid). poly (acrylic acid), p(aa), hydrogel has been synthesized by radical po...

controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (hpmc) as the matrix former. the effects of the viscosity grades of hpmc and hpmc/lactose ratio and ethylcellulose (ec)/sodium carboxymethylcellulose (nacmc) and their concentrations on the release behavior of phenobarbital from hpmc matrices were invest...

mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. several synthetic polymers are in use for this purpose. since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controlled del...

objective(s): nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. temperature and ph-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or ph. the objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer...

MICROPARTICLES OFFER VARIOUS SIGNIFICANT ADVANTAGES AS DRUG DELIVERY SYSTEMS, INCLUDING: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage ...

gastric emptying is a complex and extremely variable process. this causes the unpredictability of the bioavailability of drug delivery systems. gastro retentive drug delivery systems (grdds)s have received significant interest in the past decades as they can overcome the limitation of conventional oral controlled release drug delivery systems related to fast gastric emptying time. an optimum gr...