Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to ...

Several devices have been developed to overcome the need to co-ordinate actuation with inhalation required during use of a pressurised metered dose inhaler (MDI) and to improve drug delivery to the lung. These include spacer attachments for MDIs, dry powder inhalers and breath-actuated MDIs. The breath-actuated Autohaler (3M Pharmaceuticals) is a compact, multidose inhaler device that, unlike d...

We analyze cooperative relaying in vehicular communications by real-world measurements and compare its performance in terms of packet delivery ratios to conventional communication schemes. Results indicate that the temporal correlation of packet delivery is a key factor on whether or not cooperative relaying is of benefit compared to time diversity, where a packet is retransmitted if the first ...

Material and methods: Placentas at term were obtained immediately after cesarean delivery. Three biopsies per placenta were taken from the maternal basal surface in the delivery room. Specimens from peripheral ramifications of the villous tree (especially immature intermediate and terminal villi) were processed through conventional procedures of transmission electron microscopy and opportunely ...

The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical application. Two approaches for overcoming the factors related to the suboptimal efficacy of liposomes...

Drug delivery systems using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms. However, there remain significant problems like instability in the general application of liposomes and niosomes for drug delivery. Proniosome have the potential to become a promising drug carrier in order to give stability to niosomal drug delivery ...

Rationale: Avastin, a monoclonal antibody against vascular endothelial growth factor (VEGF), have been approved for many cancers. Recent findings suggest the existence of an intracellular VEGF pool which cannot be neutralized by conventional delivery of Avastin. Inhibiting the intracellular VEGF pool may lead to a better treatment response than the conventional strategy. The intracellular VEGF ...

Nanoparticle encapsulation has been used as a means to manipulate the pharmacokinetic (PK) and safety profile of drugs in oncology. Using pegylated liposomal doxorubicin (PLD) vs. conventional doxorubicin as a model system, we developed and experimentally validated a multiscale computational model of liposomal drug delivery. We demonstrated that, for varying tumor transport properties, there is...

Ocular drug delivery is the most fascinating and challenging task faced by pharmaceutical researchers. One of the major barriers of ocular medication is to obtain and maintain a therapeutic level at the site of action for prolonged periods of time. Major problems encountered by conventional ocular dosage forms include rapid pre-corneal drug loss due to naso-lacrimal drainage; tear turnover and ...

Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery efficiency and ultrafast sensor response, as compared to conventional fluidic systems. 70 nm sized virus like analyte solution is used to experimen...