We estimated the direct, indirect and total effects of the 13-valent pneumococcal conjugate vaccine (PCV13) on invasive pneumococcal disease (IPD) in children. A population-based cohort study followed children aged between 2.5 and 59 months between 2001 and 2014 in Navarra, Spain. IPD incidence was compared by PCV status and period. All cases diagnosed from July 2010 to December 2014 and eight ...

BACKGROUND Asthma is one of the main non-infectious diseases of the respiratory system with substantial economic burden worldwide. The objective of this study was to estimate the economic burden of adult asthma in Cyprus during 2015. METHODS A retrospective probabilistic prevalence-based cost of illness model was developed to calculate the economic burden of asthma including direct and indire...

OBJECTIVE This study was conducted to compare safety and efficacy outcomes between opioids formulated with technologies designed to deter or resist tampering (i.e., abuse-deterrent formulations [ADFs]) and non-ADFs for commonly prescribed opioids for treatment of non-cancer pain in adults. METHODS PubMed and Cochrane Library databases were searched for opioid publications between September 1,...

In this paper, we use a novel duration model to study joint retirement in married couples using the Health and Retirement Study. Whereas conventionally used models cannot account for joint retirement, our model admits joint retirement with positive probability and nests the traditional proportional hazards model. In contrast to other statistical models for simultaneous durations, it is based on...

introduction: cigarette smoking and alcohol consumption have a well-known effect on the development of upper aerodigestive tract carcinomas, but such a role for opium is questionable. this study was designed to assess the correlation between opium inhalation and cancer of the larynx and upper esophagus. materials and methods: fifty eight patients with laryngeal cancer, ninety eight patients wit...

Augmented reality (AR) is a term for a live direct or indirect view of a physical real-world environment whose elements are merged with (or augmented by) computer-generated virtual imagery – creating a mixed reality. In the case of Augmented Reality, the augmentation is conventionally in real-time and in meaningful context with environmental elements. With the help of advanced Computer Vision t...

CAM 5.2 is a murine monoclonal antibody, raised against the colon carcinoma cell line HT29, which recognises lower molecular weight intracellular cytokeratin proteins within secretory epithelia. Extensive indirect immunohistochemical studies have confirmed that this antibody stains formalin fixed (and freshly frozen) normal and malignant human tissue in a consistent manner. Reliable staining of...

BACKGROUND There are evidences of a different employment status between patients undergoing different modalities of renal replacement therapy (RRT). OBJECTIVES The present study aims to compare the indirect costs associated to morbidity in the following RRT alternatives: hemodialysis in a specialized center (HD), automated peritoneal dialysis (APD), continuous ambulatory dialysis (CAPD), and ...

Objective: The prevalence of obesity is rising in both developed and developing countries. Globally, it is estimated that nearly one billion adults are overweight at least 300 million of them are clinically obese. In Afghanistan no published data is available regarding non-communicable diseases including obesity. This paper reports the prevalence and associated risk factors of obesity among adu...