Cooperative binding effects pervade biology. Only a few basic principles are at play, but in different biological contexts cooperativity appears in distinct guises to achieve different ends. Here I discuss some of the manifestations of cooperativity that are most important in biology and drug discovery as they pertain to systems at different levels of complexity and also highlight aspects of th...

P450eryF is the only bacterial P450 to show cooperativity of substrate binding and oxidation. However, the studies reported so far have provided evidence only for homotropic cooperativity of P450eryF but not for heterotropic cooperativity. Therefore, oxidation of 7-benzyloxyquinoline (7-BQ) and 1-pyrenebutanol (1-PB) by P450eryF A245T and spectral binding of 9-aminophenanthrene (9AP) to wild-ty...

We have directly resolved in the present work interfacial composition during and after interactions of a saturated atmosphere oil vapor with soluble surfactant solutions at planar water/air interface for first time. Experiments were conducted on hexane alkyltrimethylammonium bromides sodium dodecyl sulfate to observe balance between cooperativity competition components interface. In all cases, ...

Computational thinking (CT) is an important 21st-century skill. This paper aims at more useful CT assessment. Available evaluation instruments are reviewed; two generally accepted tools selected for a comprehensive assessment: the CTt, performance test, and CTS, self-assessment instrument. The sample comprises 202 high school students from German-speaking Switzerland. Concerning Rasch-scalabili...

P450eryF is the only bacterial P450 to show cooperativity of substrate binding and oxidation. However, the studies reported so far have provided evidence only for homotropic cooperativity of P450eryF but not for heterotropic cooperativity. Therefore, oxidation of 7-benzyloxyquinoline (7-BQ) and 1-pyrenebutanol (1-PB) by P450eryF A245T and spectral binding of 9-aminophenanthrene (9AP) to wild-ty...

This paper reports the syntheses, crystal structures, magnetics and spectroscopic properties of high-spin (HS) salts formula [Mn(salk-N-1,5,8,12)]Y·S (Y = AsF6 for 1, Y BF4, S CH3OH 2, PF6, 3), where (salk-N-1,5,8,12)2− (2,2ʹ-((2E,14E)-3,7,10,14-tetraazahexadeca-2,14-diene-2,15-diyl)diphenolate) is a hexadentate Schiff-base ligand. Crystal structural analysis indicates that extensive hydrogen b...