Microwave Plasma Enhanced Chemical Vapor Deposition (MPECVD) is an innovative technique allowing the direct preparation, at low temperature, of different valence states of copper (Cu°, Cu, Cu). The precursor used is a volatile metalorganic one (copper acetylacetonate) with helium as a carrier gas. The precursor is then transported in a remote plasma of Ar, A1/O2 or A r / ^ O gas at low pressure...

Maryon EB, Molloy SA, Kaplan JH. Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1. Am J Physiol Cell Physiol 304: C768–C779, 2013. First published February 20, 2013; doi:10.1152/ajpcell.00417.2012.—Copper is an essential micronutrient. Following entry via the human copper transporter 1 (hCTR1), copper is delivered to several copper chaperones, which ...

The utility of the extensible systematic force field (ESFF) was tested for copper(II) binding to a 34-amino-acid Cu(II) peptide, which includes five histidine residues and is the putative copper-binding site of lysyl oxidase. To improve computational efficiency, distance geometry calculations were used to constrain all combinations of three histidine ligands to be within bonding distance of the...

According to X-ray single-crystal structure analysis, {[Cu(II)(en)2]2[Cu(I)2(CN)6]}[Cu(II)(en)2]2[Cu(I)(CN)3]2.2H2O contains copper in four different coordination environments: trigonal planar, square planar, square pyramidal and tetrahedral. The different coordination geometries of copper were investigated by quantum chemical calculations of model compounds, thus allowing to tentatively assign...

Seleniumand sulfur-containing compounds can act as antioxidants by binding copper. To determine how this copper coordination results in the observed antioxidant activity, biologically relevant Cu and Cu complexes with the formulae [Cu(dmit)3] + (3), [Cu(dmise)4] + (4a), and [TpmCu(MISeox)] (6) (dmise = N,N′-dimethylimidazole selone; dmit = N,N′-dimethylimidazole thione; MISeox = bis(1methylimid...

Crd1 (Copper response defect 1), which is required for the maintenance of photosystem I and its associated light-harvesting complexes in copper-deficient (-Cu) and oxygen-deficient (-O(2)) Chlamydomonas reinhardtii cells, is localized to the thylakoid membrane. A related protein, Cth1 (Copper target homolog 1), is shown to have a similar but not identical function by genetic suppressor analysis...

Application of copper-based fungicide is still the most popular and effective means of controlling black pod disease among Nigerian cocoa farmers. There are two possible pathways through which copper gets into cocoa beans on the field: Uptake and translocation of Cu from soil and Permeation of cocoa pod cuticle by copper after fungicide application. Records showing quantitative contribution of ...

The pathogenic mutant (P174L) of human Sco1 produces respiratory chain deficiency associated with cytochrome c oxidase (CcO) assembly defects. The solution structure of the mutant in its Cu(I) form shows that Leu-174 prevents the formation of a well packed hydrophobic region around the metal-binding site and causes a reduction of the affinity of copper(I) for the protein. K(D) values for Cu(I)W...

Cells regulate copper levels tightly to balance the biogenesis and integrity of copper centers in vital enzymes against toxic levels of copper. PIB -type Cu(+)-ATPases play a central role in copper homeostasis by catalyzing the selective translocation of Cu(+) across cellular membranes. Crystal structures of a copper-free Cu(+)-ATPase are available, but the mechanism of Cu(+) recognition, bindi...

Speciation and possible reaction paths of nanosize copper pollutants extracted with a RTIL (room-temperature ionic liquid ([C4mim][PF6], 1-butyl-3-methylimidazolium hexafluorophosphate)) have been studied in the present work. Experimentally, in a very short contact time (2 min), 80-95% of nanosize CuO as well as other forms of copper (such as nanosize Cu, Cu2+, or Cu(II)(ads) (in the channels o...