Redox active transition metal ions (e.g., iron and copper) have been implicated in the etiology of many oxidative stress-related diseases including also neurodegenerative disorders. Unbound copper can catalyze formation of reactive oxygen species (hydroxyl radicals) via Fenton reaction/Haber-Weiss chemistry and therefore, under physiological conditions, free copper is potentially toxic and very...

Lytic polysaccharide monooxygenases (LPMOs) exhibit a mononuclear copper-containing active site and use dioxygen and a reducing agent to oxidatively cleave glycosidic linkages in polysaccharides. LPMOs represent a unique paradigm in carbohydrate turnover and exhibit synergy with hydrolytic enzymes in biomass depolymerization. To date, several features of copper binding to LPMOs have been elucid...

Ocean acidification (OA) is expected to indirectly impact biota living in contaminated coastal environments by altering the bioavailability and potentially toxicity of many pH-sensitive metals. Here, we show that OA (pH 7.71; pCO2 1480 μatm) significantly increases the toxicity responses to a global coastal contaminant (copper ~0.1 μM) in two keystone benthic species; mussels (Mytilus edulis) a...

Three-dimensional cubic Fm3[combining macron]m mesoporous copper-containing ethane-bridged PMO materials have been prepared through a direct-synthesis method at room temperature in the presence of cetyltrimethylammonium bromide as surfactant. The obtained materials have been unambiguously characterized in detail by several sophisticated techniques, including XRD, UV-Vis-Dr, TEM, elemental mappi...

Control over assembly, orientation, and defect-free growth of metal-organic framework (MOF) films is crucial for their future applications. A layer-by-layer approach is considered a suitable method to synthesize highly oriented films of numerous MOF topologies, but the initial stages of the film growth remain poorly understood. Here we use a combination of infrared (IR) reflection absorption sp...

Vivid blue inclusions in white whewellite or weddellite, occurring within the medulla of four lichen species growing on copper-bearing rocks, have been identified as the hydrated copper oxalate, moolooite, CUC204. nH20 (n ~ 0.4-0.7), by infrared spectroscopy and X-ray powder diffraction. The mineral is believed to have been formed by reaction between oxalic acid secreted by the lichen and groun...

Copper is an essential micronutrient for most living organisms, serving as a redox-active cofactor for important enzymes such as the terminal respiratory oxidases and superoxide dismutase. However, in excess copper can be extremely toxic, due in part to this same redox-activity by which copper ions can catalyse the production of deleterious reactive oxygen species (ROS), and also due to its pro...

I report a facile wet-chemical method for the synthesis of one-dimensional copper hydroxide nitrate nanostructures in 2-propanol under solvothermal conditions. Single-crystalline nearly monodispersed copper hydroxide nitrate nanorods and nanobelts with selected breadths in the range of 100 nm to 1 μm have been successfully prepared by a solvothermal method through controlling the experimental p...

Sulfur-containing nitriles have important research value in the life sciences due to their diverse biological activities resulting from the sulfur and cyano functional groups. Herein, a copper-catalyzed cyanothiolation of N-tosylhydrazones with thiocyanates to generate a-arylthioalkanenitriles bearing sulfur-substituted quaternary carbon center atoms has been described. This novel protocol invo...