A report of a woman in her fifties with Schnyder's crystalline stromal dystrophy is presented. There is no personal or family history of hypercholesterolaemia. A full thickness corneal disc was removed before grafting and examined by polarised light, histochemistry, and electron microscopy. Specific lipid histochemical methods showed deposits of cholesterol and cholesterol ester in the superfic...

purpose : to review ocular surface abnormalities caused by exposure to mustard gas and current approaches to manage its delayed-onset complications methods : a total of 198 medical articles related to mustard gas were reviewed using known international medical databases, 114 articles were more relevant to the main aim were selected. results : mustard gas-related ocular injuries can be divided i...

bietti’s crystalline dystrophy (bcd) is a rare disease presenting with the appearance of intraretinal crystalline deposits and varying degrees of chorioretinal atrophy commencing at the posterior pole. within time, intraretinal crystals gradually disappear and chorioretinal atrophy extends beyond the macula even resulting in complete chorioretinal atrophy. concomitant corneal crystals can be ...

PURPOSE The presence of corneal opacities associated with dacryoadenitis and lacrimal gland destruction has led investigators to consider MRL/Mp mice as models for band keratopathy and Sjögren syndrome. In this study, the authors examined the time course of the corneal opacification and investigated whether the opacities were associated with altered serum levels of parathyroid hormone, calcium,...

PURPOSE To describe in vivo confocal microscopy findings in patients with different stages of amiodarone-induced keratopathy, and correlate biomicroscopy stages with confocal stages. METHODS Twenty eyes of 10 patients (6 men and 4 women), who receive treatment with amiodarone were selected for the study with confocal microscopy (MC). RESULTS The average age was 58 +/- 6.2 years (50-66 years...

AIM To report the quantitation of the lipid composition of a corneal button from a Japanese woman in her 60s with clinically and histopathologically proved Schnyder's corneal dystrophy. METHODS Total lipids extracted from the corneal button of the patient were analysed by the method of thin layer chromatography flame ionisation detection. Two different solvent systems were used for neutral li...

PURPOSE The local deposition of fibrinogen and other plasma products from tears within corneal wounds and the expression of plasminogen activator by corneal epithelial cells suggest that the coagulation and fibrinolytic systems play an important role in corneal wound healing. The authors used mouse lines deficient in plasminogen (Plg), fibrinogen (Fib), or both to elucidate the roles of these k...

PURPOSE Macular corneal dystrophy (MCD) is a rare corneal dystrophy that is characterized by abnormal deposits in the corneal stroma, keratocytes, Descemet's membrane, and endothelium, accompanied by progressive clouding. It has been classified into three immunophenotypes--MCD types I, IA, and II--according to the serum level of sulfated keratan sulfate (KS) and immunoreactivity of the corneal ...

PURPOSE To determine the genetic basis for lattice corneal dystrophy (LCD) in an extensively studied family. METHODS Ten affected family members were examined clinically, and three individuals were studied with in vivo confocal microscopy and optical coherence tomography (OCT). Corneal tissues from eight affected family members were examined histopathologically. The status of the transforming...