The cornea is a multi-layered structure which allows fine refraction and provides both resistance to external insults adequate transparency. corneal endothelium ensures stromal hydration, failure of which, such as in Fuchs endothelial dystrophy, after trauma or aging, may lead loss transparency induce blindness. Currently, no efficient therapeutic alternatives exist except for grafting. Thus ti...

PURPOSE To evaluate the effects of pirfenidone nanoparticles on corneal re-epithelialization and scarring, major clinical challenges after alkali burn. METHODS Effect of pirfenidone on collagen I and α-smooth muscle actin (α-SMA) synthesis by TGFβ induced primary corneal fibroblast cells was evaluated by immunoblotting and immunocytochemistry. Pirfenidone loaded poly (lactide-co-glycolide) (P...

Background: The determination of common diseases in a region is a medical and health priority of that region. Ocular emergencies can cause permanent vision loss if they are not recognized and treated promptly.  Preserve vision of patients, We arranged this study  in Moradi hospital (Kerman, Iran), to estimate our regional situation. Materials and Methods: In this cross-sectional stud...

Patients suffering from various corneal diseases and waiting for keratoplasty have been immunologically investigated in order to establish sensitisation to corneal antigens. The presence of lymphocytes sensitised to the soluble from human corneas, bovine corneal epithelium, and bovine corneal stroma, which all possess common antigenicity, could be demonstrated in 30%, 50%, and 23%, respectively...

OBJECTIVE It is to study the pattern of corneal diseases (including injuries) in paediatric population in a tertiary eye care center. MATERIALS AND METHODS A descriptive, cross sectional study was carried out in a tertiary eye care center which included 176 cases. RESULTS Out of 176 cases studied, 6 cases (3.4%) presented with congenital causes, 4 cases (2.27%) were of dystrophy and ectasia...

Over the last two decades, there has been growing interest in assessing corneal biomechanics different diseases, such as keratoconus, glaucoma, and disorders. Given interaction structural continuity between cornea sclera, evaluating may give us further insights into pathogenesis, diagnosis, progression, management of glaucoma. Therefore, some authorities have recommended baseline evaluations al...