نتایج جستجو برای: corneal neovascularization

تعداد نتایج: 38838  

2013
Metin EKİNCİ Zeliha YAZAR Seyit Ali BİNGÖL

The aim of this study was to evaluate the effects of subconjunctival ranibizumab and bevacizumab injection on angiogenesis in the rabbit cornea. The corneas of 24 New Zealand rabbits were cauterized with silver nitrate to induce neovascularization. The eyes were irrigated with 10 ml of 0.9% saline solution. The alkaline burns were similar in all the rabbits. At the 24 h after cauterization, the...

Journal: :Investigative ophthalmology & visual science 2011
Takayoshi Sumioka Norihito Fujita Ai Kitano Yuka Okada Shizuya Saika

PURPOSE This study investigated the effects of loss of tenascin C (TNC) in the development of neovascularization in a corneal stroma in mice. Cell culture study was also conducted to clarify the roles of TNC in the expression of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)β1 in fibroblasts and macrophages. METHODS Ocular fibroblasts and macrophages from wild-...

Journal: :Cancer research 2007
Taturo Udagawa Amy E Birsner Mark Wood Robert J D'Amato

Radiation can potentially suppress neovascularization by inhibiting the incorporation of hematopoietic precursors as well as damaging mature endothelial cells. The purpose of these studies was to quantify the effect of radiation on angiogenesis and to examine the relationship between bone marrow reconstitution and neovascularization. Immune competent, severe combined immunodeficient, RAG1-defic...

Journal: :American journal of ophthalmology 2003
Alison L Wong Barry A Weissman Bartly J Mondino

PURPOSE To report a case of severe bilateral deep stromal neovascularization and opacification associated with unmonitored contact lens wear. DESIGN Observational case report. METHODS A 46-year-old woman who had been using hydrogel contact lenses bought on the Internet without a prescription for 5 years was found to have dense, bilateral corneal opacities with deep stromal neovascularizatio...

2011
Naiyang Li Xiaoran Wang Pengxia Wan Minghai Huang Zheng Wu Xuanwei Liang Ying Liu Jian Ge Junqi Huang Zhichong Wang

PURPOSE Tectonic lamellar keratoplasty (TLKP) is a primary surgical procedure to improve the condition of the recipient bed in high-risk corneal transplantation. It is usually performed for a secondary optical penetrating keratoplasty (PKP). The present study was undertaken to explore a new strategy for TLKP using acellular corneal stroma (ACS) prepared by decellularization. METHODS ACS for T...

Journal: :Molecular Vision 2009
Kyoko Fujita Takeshi Miyamoto Shizuya Saika

PURPOSE To examine if sonic hedgehog (Shh) is involved in tissue neovascularization by using cell culture and an animal cornea. METHODS The effects of exogenous Shh (5.0 nM), vascular endothelial growth factor (VEGF), and/or a Shh signal inhibitor (2.5 or 10.0 muM cyclopamine) on vessel-like tube formation of vascular endothelial cells were examined in vitro. The effects of Shh on the express...

Journal: :Journal of Ocular Pharmacology and Therapeutics 2013

Journal: :Middle East African Journal of Ophthalmology 2012

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