Neurotrophic keratitis is a degenerative disease of the cornea caused by reduced corneal innervation. Trauma, tumors, inflammatory lesions and surgical procedures can damage the first branch of the trigeminal nerve on its entire course from brainstem to and within the cornea. Loss or reduction of corneal innervation leads to a reduced aqueous phase of the tear film and due to reduced supply wit...

Purpose. To report an unusual case of severe bilateral fungal keratitis following laser in situ keratomileusis (LASIK). Method. A 48-year-old man developed bilateral diffuse corneal infiltration two weeks after LASIK. The corneal scrapings revealed fungal filaments but cultures were negative. Results. The corneal ulceration was improved on the left eye whereas spontaneous perforation occurred a...

Alterations in corneal innervations result in impaired corneal sensation, severe dry eye and damage to the epithelium that may in turn lead to corneal ulcers, melting and perforation. These alterations can occur after refractive surgery. We have discovered that pigment epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA or the docosanoid bioactive neuroprotectin D1 (NPD1)) induces n...

INTRODUCTION Biomechanical changes in the cornea during pregnancy might lead to pathological conditions such as corneal perforation or melting. CASE PRESENTATION A 33-year-old Asian female who underwent penetrating keratoplasty in both eyes developed corneal melting in the right eye and marginal keratitis in the left eye in her fifth month of pregnancy. Marginal keratitis in the left eye imme...

Purpose To describe a case of peripheral ulcerative keratitis in the setting of autoimmune hepatitis and possible overlap syndrome with primary sclerosing cholangitis. Case Report A 48-year-old African American female with autoimmune hepatitis with possible overlap syndrome with primary sclerosing cholangitis presented with tearing, irritation, and injection of the left eye that was determine...

Residual refractive error often complicates penetrating keratoplasty (PKP) and can be treated surgically in patients who are contact lens intolerant. Both photorefractive keratectomy and laser in situ keratomileusis (LASIK) have been used to reduce postoperative myopia and astigmatism following PKP. Reported complications of LASIK following PKP include irregular astigmatism, photoablation decen...

purpose: to evaluate the effect of aamniotic mmembrane ttransplantation (amt) in the management of acute severe ocular chemical burns. methods: this randomized clinical trial was performed in eligible patients with grade iii & iv acute chemical burn who randomly received conventional medical therapy (15 eyes) versus combined medical & amniotic membrane transplantation (15 eyes). main outcome me...

Purpose: To determine the outcomes of penetrating keratoplasty (PK) for treatment of corneal scarring caused by Herpes simplex virus (HSV) keratitis, and whether the corneal scar type affects treatment outcome. Methods: A retrospective analysis of patients who underwent PK for HSV-related corneal scarring between January 2008 and July 2011 was performed. The patients were categorized into two...