In the genotyped-proband design, a proband is selected based on an observed phenotype, the genotype of the proband is observed, and then the phenotypes of all first-degree relatives are obtained. The genotypes of these first-degree relatives are not observed. Gail et al. [(1999) Genet Epidemiol] discuss likelihood analysis of this design under the assumption that the phenotypes are conditionall...

A series of tests, including gastro-oesophageal sphincter pressure measurement, short-term pH tests, and 15-hour overnight oesophageal pH recording were applied to 42 normal subjects and 214 patients with typical reflux symptoms. The results were compared by multivariate discriminant analysis. Sphincter pressure measurements misclassified 32%, stressed provocative manoeuvres 14-5%, and the best...

A set of novel correlation tests using omni-directional cross-correlation functions (ODCCFs), which are based on the first order cross-correlation functions (CCF), are proposed in the present study to comprehensively detect nonlinear relationships between variables. Then the ODCCFs are combined into a set of concise formulations to provide better illustration of detected correlations and reduce...

N. E. Savin Department of Economics, University of Iowa, Iowa City, IA 52242. August, 2008 (forthcoming in Journal of Business and Economic Statistics) ABSTRACT This paper considers testing the null hypothesis that a times series is uncorrelated when the time series is uncorrelated but statistically dependent. This case is of interest in economic and finance applications. The GARCH (1, 1) model...

For software products to succeed they have to satisfy customer expectations, including usability aspects of the software. Early during the development cycle important design decisions are made for projects that are typically on restricted schedules and budgets. There is a need to support this decision making process, by empowering the decision makers with better tools and techniques. In this re...

Biologists frequently summarize multivariate data from n populations by computing some measure of distance between populations. The problem then arises of comparing two such pairwise distance matrices based on different characters. A permutation test for correlation between distance matrices is proposed. This test, based on Kendall's tau statistic, is compared to Pearson's product-moment and Sp...

Computing-related programmes and modules have many problems, especially related to large class sizes, large-scale plagiarism, module franchising, and an increased requirement from students for increased amounts of hands-on, practical work. This paper presents a practical computer networks module which uses a mixture of online examinations and a practical skills-based test to assess student perf...

The objective was to determine whether mismatch negativity (MMN) is suitable to supplement subjective psychometric subtests of central hearing. We assessed 13 healthy children and 32 children with central auditory processing disorder (CAPD). Three different types of sound deviants were presented in a multi-deviant MMN design. At group level, the incidence of MMN was always higher in clinically ...

We use meta analytic combination procedures to develop new tests for panel cointegration. The main idea consists in combining p-values from time series cointegration tests on the different units of the panel. The tests are robust to heterogeneity as well as to cross-sectional dependence between the different units of the panel. To achieve the latter, we employ a sieve bootstrap procedure with j...