TOPIC: Obstructive Lung Diseases TYPE: Original Investigations PURPOSE: Chronic oral corticosteroid (OCS) treatment improves asthma control but is associated with severe side effects. Dupilumab (DPL), a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4/-13, key and central drivers of type 2 inflammation in multiple diseases. In phase 3 VENTURE study (NCT025...

BACKGROUND Peripheral muscle strength and endurance are decreased in patients with chronic pulmonary diseases and seem to contribute to patients' exercise intolerance. However, the authors are not aware of any studies evaluating peripheral muscle function in children with asthma. It seems to be implied that children with asthma have lower aerobic fitness, but there are limited studies comparing...

BACKGROUND Asthma is the most common chronic disease in childhood and places a significant burden on public and private health systems. This retrospective cohort analysis utilised administrative healthcare claims data (US Clinformatics™ Multiplan database; compliant with the US Department of Health & Human Services Health Insurance Portability and Accountability Act) to characterise asthma exac...

OBJECTIVE To review the efficacy and safety of inhaled corticosteroids (ICSs) when used to reduce daily oral corticosteroid (OCS) requirements in patients with severe persistent asthma and periodic requirements in patients with acute asthma exacerbations. DATA SOURCES Clinical studies of the OCS-sparing effects of ICSs were located by searching MEDLINE databases from 1966 onward using the ter...