Many expensive treatments have been developed for Parkinson's disease (PD), and a good cost-utility analysis is required. Quality-adjusted life-years (QALY) allows comparison of the cost-utility of different medical conditions. If a treatment strategy gives a patient an extra but unhealthy year, the QALY he obtained will be less than one. When a therapeutic strategy is more effective, but cause...

Consider a data publishing setting for a data set with public and private features. The objective of the publisher is to maximize the amount of information about the public features in a revealed data set, while keeping the information leaked about the private features bounded. The goal of this paper is to analyze the performance of privacy mechanisms that are constructed to match the distribut...

Educational needs assessments (hereafter NAs) are inattentive to cost considerations and are frequently dominated by elite stakeholder groups. In this article I make a case for adopting a cost-utility approach, illustrating the argument with data generated in a NA of central library services in a Canadian school district. Using survey data from eight stakeholder groups, I found that (1) NAs bas...

BACKGROUND Galactosemia is a congenital metabolic disorder that can damage the health of a newborn. Screening is an important step to prevent and treat this condition. Due to increasing health care costs and limited financial resources of health systems, the most suitable economic analysis tool should be applied. The aim of this study was to analyze the cost-utility of neonatal screening progra...

Ischemic stroke is the third highest cause of death in the United Kingdom and a leading cause of disability. The overall incidence is postulated to increase over the next 5 years by the WHO. The economic burden of stroke is estimated at £9 billion per year in the United Kingdom ($38 billion in the United States) and is estimated to rise. Intravenous tissue-type plasminogen activator (IV-tPA) fo...

In addressing the topic of decision making in the water sector, what has been suggested to be useful up to this point is benchmarking. This paper aims at exploring the relationship between the Operating Cost Coverage Index and customer complaints about water and wastewater services for 1898 water utilities in 11 countries, i.e., Australia, Bangladesh, Brazil, Lithuania, Peru, Poland, Russia, Se...

BACKGROUND The continuation of trastuzumab beyond progression in combination with capecitabine as secondary chemotherapy for HER2-positive metastatic breast cancer (MBC) prolongs progression-free survival without a substantial increase in toxicity. PATIENTS AND METHODS A Markov cohort simulation was used to follow the clinical course of typical patients with MBC. Information on response rates...

Much work has been done on the impact of mergers and acquisitions on the shareholders of both acquiring and target firms (see Asquith et al. [1983], Bradley et al.[1988], Jarrell and Poulsen [1989], Jensen and Ruback [1983], and Travlos [1987]). Those studies generally indicate favorable stock price responses for target firms, and slight, to no, stock price response for acquiring firms. Recent ...