BACKGROUND Spontaneous reporting of adverse drug reactions (ADRs) is fundamental to drug safety surveillance (pharmacovigilance); however, substantial under-reporting exists and is the main limitation of the system. Several factors could favour under-reporting. OBJECTIVE The aim of this pilot study was to assess the effect of regular visits of a Clinical Research Assistant (CRA) on the improv...

In this paper, the common centralized DEA models are extended to the bi-level centralized resource allocation (CRA) models based on revenue efficiency. Based on the Karush–Kuhn–Tucker (KKT) conditions, the bi-level CRA model is reduced to a one-level mathematical program subject to complementarity constraints (MPCC). A recurrent neural network is developed for solving this one-level mathematica...

Infeasible solutions or negative expected values of future climate information are undesired problems if policies adopted under Cost-Effectiveness Analysis (CEA) to reach uncertain temperature targets. Cost-Risk (CRA) was developed resolve these issues. It allows for a trade-off between welfare losses mitigation and avoided risk transgressing target with certain probability compliance (Safety)....

Gastrointestinal (GI) bacteria sense diverse environmental signals as cues for differential gene regulation and niche adaptation. Pathogens such as enterohemorrhagic Escherichia coli (EHEC), which causes bloody diarrhea, use these signals for the temporal and energy-efficient regulation of their virulence factors. One of the main virulence strategies employed by EHEC is the formation of attachi...

OBJECTIVES In many academic emergency departments (ED), physicians are asked to record clinical data for research that may be time consuming and distracting from patient care. We hypothesized that non-medical research assistants (RAs) could obtain historical information from patients with acute abdominal pain as accurately as physicians. METHODS Prospective comparative study conducted in an a...

Context. In star-forming regions like Taurus-Auriga, it has been found that most young stars are born as multiples, which theories for star formation should definitely take into account. The R CrA star-forming region has a small dark cloud with quite a number of protostars, T Tauri stars, and some Herbig Ae/Be stars, plus a number of weak-line T Tauri stars around the cloud found by ROSAT follo...

Peribronchial inflammation contributes to the pathophysiology of allergic asthma. In many vascular beds, adhesive interactions between leukocytes and the endothelial surface initiate the recruitment of circulating cells. Previous studies using OVA-induced airway hyperreactivity indicated that P-selectin, a member of the selectin family expressed by activated platelets and endothelium, contribut...

An important and difficult issue in designing a Fuzzy Inference System (FIS) is the specification of fuzzy sets, and fuzzy rules. The aim of this paper is to demonstrate how an additional qualitative information, i.e., monotonicity property, can be exploited and extended to be part of an FIS designing procedure (i.e., fuzzy sets and fuzzy rules design). In this paper, the FIS is employed as an ...

The central retinal artery (CRA) is a branch of the ophthalmic artery, which is the first branch of the internal carotid artery. The CRA supplies blood to the surface of the optic disc. From here it divides into two main branches (superior and inferior); these then further divide into temporal and nasal branches, which supply blood to the four quadrants of the retina. The outer retina is suppli...