Let $D$ be a finite simple digraph with vertex set $V(D)$ and arcset $A(D)$. A twin signed total Roman dominating function (TSTRDF) on thedigraph $D$ is a function $f:V(D)rightarrow{-1,1,2}$ satisfyingthe conditions that (i) $sum_{xin N^-(v)}f(x)ge 1$ and$sum_{xin N^+(v)}f(x)ge 1$ for each $vin V(D)$, where $N^-(v)$(resp. $N^+(v)$) consists of all in-neighbors (resp.out-neighbors) of $v$, and (...

Vitamin D is a factor that plays a significant role in calcium-phosphate balance. It has an effect on bone metabolism and also has modulator and anti-inflammatory activity. It is claimed that vitamin D inhibits immunological reactions with Th1 and Th17 lymphocytes. The influence of vitamin D on Th2 lymphocytes is not clear. The main effect of vitamin D is probably the activation of Treg lymphoc...

BACKGROUND Patient-reported outcomes (PRO) that comprise all self-reported measures by the patient are important as endpoint in clinical trials and epidemiological studies. Models from the Item Response Theory (IRT) are increasingly used to analyze these particular outcomes that bring into play a latent variable as these outcomes cannot be directly observed. Preliminary developments have been p...