The systematic review and meta-analysis performed by Tasche and colleagues appears to have been carried out with commendable thoroughness. The results seem clear cut: sodium cromoglycate is ineVective as maintenance therapy in children with asthma. However, their conclusions are not objective but depend in the final analysis on their multivariate regression model. Perhaps this is where the most...

Anisometric DNA nanoparticles with precisely tailored size and shape are prepared by three-dimensional folding of – origami marked a fluorescent intercalating dye (YOYO-1), stabilised silica, dispersed in lyotropic chromonic liquid crystal (an aqueous solution disodium cromoglycate). Observations total internal reflection fluorescence microscopy indicate that the luminescent stable dispersion a...

The effects of sodium cromoglycate and ketotifen were studied in a group of 20 patients in whom fish repeatedly provoked an attack of wheezing and dyspnoea within one hour of its being eaten. Fish ingestion resulted in a fall in forced expiratory volume in one second (FEV1) of at least 15%. All patients had a weal greater than 4 mm in response to fish antigen in the skinprick test and most had ...

Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal c...

These results in a few patients suggest that doxantrazole may be valuable in the treatment of asthma. A similar protection against asthma induced by allergen challenge has been reported for the orally administered compound AH 7725,3 but the value of disodium cromoglycate was proved by long-term trials4 rather than such singledose studies. Further clinical trials are obviously needed to establis...

I. The protective effect of different particle sizes of sodium cromoglycate (SCG) was assessed by exercise challenge in nine asthmatic patients. 2. SCG particles of 11.7 pm or 2 0 pm mass median diameter were generated by a spinning disc and compared with lactose placebo particles. The drugs were given 10 min before a 6 min run on a treadmill. 3. The post-exercise bronchoconstriction caused a 4...

Using sodium cromoglycate as a non-toxic marker, we assessed the delivery of aerosol to nine wheezy infants and seven healthy adults. The drug was delivered to the infants by face mask and spacer device from a metered dose inhaler, and by face mask and nebuliser to the infants and the adults who breathed though their noses. The concentration of sodium cromoglycate was estimated in timed urine c...