Within a large family of crossover designs this paper characterizes the mathematical structures of A-optimal and A-efficient crossover designs for the purpose of statistical comparison between t experimental treatments with a control (standard) treatment. It further guides the user how to go about the construction of these designs and if needed doing the last minute modifications. To demonstrat...

June 29, 2010 Version 2.5.3 Date 2010-06-25 Title Average bioequivalence and bioavailability data analysis tool Author Hsin-ya Lee, Yung-jin Lee Maintainer Yung-jin Lee Depends R (>= 2.10.0), reshape, nlme, sciplot, plotrix, ICSNP, gdata Description An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental anal...

The paper presents the design of a novel ultra-wideband microwave crossover for the use in microstrip circuits. The proposed structure includes a double microstrip-coplanar waveguide (CPW) vertical interconnect in single-layer substrate technology which allows an inclusion of a finite-width coplanar waveguide (CPW) on the top side of the substrate to achieve the required cross-link. The present...

Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e. I clusters randomized to each treatment), only a few examples of CRTs using cro...

Sample size calculation formulas for testing equality, noninferiority, superiority, and equivalence based on odds ratio were derived under both parallel and one-arm crossover designs. An example concerning the study of odds ratio between a test compound (treatment) and a standard therapy (control) for prevention of relapse in subjects with schizophrenia and schizoaffective disorder is presented...

In two consecutive years, we conducted this study in t\'o'0 sections of a lower-level engineering mechanics course, Statics. One author taught both sections and a crossover design of experiment was used. In a crossover design, one section was randomly chosen to receive feedback with handheld computers (the "treatment" group) while the other received the "control," which was either a feedback sy...

This study focuses on the shape optimization of concrete gravity dams considering dam–water–foundation interaction and nonlinear effects subject to earthquake. The concrete gravity dam is considered as a two–dimensional structure involving the geometry and material nonlinearity effects. For the description of the nonlinear behavior of concrete material under earthquake loads, the Drucker–Prager...

real coded genetic algorithm, rcga, is the type of ga which operates on chromosomes with real valued parameters. different mutation and crossover operations are defined for rcga. one usable crossover for this kind of ga is to consider its chromosomes simply as bit strings and utilize the same operations as binary coded ga. in this paper, we attempt to show that this kind of crossover can not ha...

The case-crossover design compares exposures during the period of time of failure with one or more periods when failure did not occur and evaluates the potential excess risk using conditional logistic regression. In this simulation study, we applied several control sampling approaches to control for confounding by various temporal patterns of an exposure variable and evaluated the usefulness of...