Recombination-mediated repair plays a central role in maintaining genomic integrity during DNA replication. The human Mus81-Eme1 endonuclease is involved in recombination repair, but the exact structures it acts on in vivo are not known. Using kinetic and enzymatic analysis of highly purified recombinant enzyme, we find that Mus81-Eme1 catalyzes coordinate bilateral cleavage of model Holliday-j...

p53 plays critical roles in regulating cell cycle, apoptosis, senescence and metabolism and is commonly mutated in human cancer. These roles are achieved by interaction with other proteins, but particularly by interaction with DNA. As a transcription factor, p53 is well known to bind consensus target sequences in linear B-DNA. Recent findings indicate that p53 binds with higher affinity to targ...

This paper formulates a support time game arising in one-on-one air combat with medium range air-to-air missiles. The game model provides game optimal support times of the missiles that can receive target information from the launching aircraft for selectable support times. The payoffs of the game are formulated as aweighted sumof the probabilities of hit to the adversary and own survival. Unde...

2 INTRODUCTION The guided missile provides military forces with the capability to deliver munitions rapidly and precisely to selected targets at a distance. This capability establishes an effective means to conduct a wide variety of military missions that range from denying the enemy communications or supply routes, to establishing air superiority, to performing anti-ship cruise missile or ball...

Cruciform specimens are one of the most common used to measure plane mechanical properties materials. Two significant difficulties in designing cross reducing stress concentration at intersection arms and improving stress/strain uniformity gauge area. The shape border cruciform specimen is tightly related above two. Due lack guidelines for design specimens, optimizing an urgent problem be solve...

Attacking a naval vessel with multiple missiles is an important way to improve the hit rate of missiles. Missile-borne radars need complete detection and antijamming tasks guide missiles, but communication between these often difficult. In this paper, optimization method based on multi-agent reinforcement learning proposed for collaborative against one vessel. We consider as player make their c...

Lethality evaluation tests of anti-armor missile systems require flight-test of tactical missiles against threat targets under highly controlled impact conditions. Variables such as terminal dive angle, impact velocity, missile orientation at impact, hit-point on the target, and shot-line through the target all must be carefully controlled and documented to properly evaluate and analyze the dam...

Extended benzobisoxazole-based cruciforms, efficiently synthesized using acyl condensations and Sonogashira couplings, form highly ordered two-dimensional sheets in the solid state.

This paper tells about the CFD analysis of 2D Canard arrangement in supersonic cruise missiles. High heat dissipation rate causes the Canards to reduce its primary work of providing rotational stability to missile. This paper discusses about the criteria of choosing notched canard model against the present model. The models were designed in GAMBIT and analysed using FLUENT. Various pressure, te...