Directed delivery of EGF receptor (EGFR) ligands to the apical or basolateral surface is a crucial regulatory step in the initiation of EGFR signaling in polarized epithelial cells. Herein, we show that the EGFR ligand betacellulin (BTC) is preferentially sorted to the basolateral surface of polarized MDCK cells. By using sequential truncations and site-directed mutagenesis within the BTC cytop...

The search for adsorbents flue gas desulfurization processes is a current interest. For the first time, comparative experimental study of SO2 adsorption by porous materials including prototypical metal–organic frameworks NH2-MIL-101(Cr), Basolite F300 (Fe-1,3,5-BTC), HKUST-1 (Cu-BTC), zeolitic imidazolate (ZIF)-8, ZIF-67, alumosilicate Zeolite Y, silicoaluminumphosphate (SAPO)-34, Silica gel 60...

Betacellulin (BTC), a member of the epidermal growth factor (EGF) family of peptide growth factors, was purified from a growth-factor-enriched whey fraction of bovine milk by a combination of ion-exchange chromatography, gel-filtration chromatography, affinity chromatography and reverse-phase HPLC. Bovine BTC (bBTC) had an apparent molecular mass of 21-22 kDa on SDS/PAGE and exists in a glycosy...

The asymmetric unit of the title compound, [Zn3(HCO2)3(C9H3O6)(C3H7NO)3] n , contains one Zn ion, one formate ligand, one N,N-di-methyl-formamide (DMF) ligand and one-third of a benzene-1,3,5-tri-carboxyl-ate (btc) ligand situated on a crystallographic 3 axis. Each Zn(II) atom is coordinated by one O atom from a DMF ligand, two O atoms from two btc ligands and three O atoms from three formate l...

A novel ligand, 5,5'-(2,2'-bipyridine-4,4'-diyl)-bis(thiophene-2-carboxylic acid) (BTC), and its Ru(II) complex (BTC-1) in which the anchoring group is attached to the thiophene units were developed. Using a low-volatility electrolyte and 3.3 mum mesoporous TiO2 films BTC-1 achieved a solar-to-electricity conversion efficiency of 6.1%, compared to 4.8% for N719 under the same experimental condi...

Biliary tract carcinoma (BTC) has a poor prognosis due to limited treatment options. There is, therefore, an urgent need to identify new targets and to design innovative therapeutic approaches. Among potential candidatemolecules, we evaluated the nonreceptor tyrosine kinase Src, observing promising antitumor effects of its small-molecule inhibitor saracatinib in BTC preclinical models. The pres...

Image compression is used to reduce the size of digital image files in order to lessen the physical storage and transmission bandwidth costs. The main challenge in image compression is reducing the file size while maintaining much of the visual information. In this study, we explore one class of image compression techniques – the Block Truncation Coding (BTC) – and propose a new variant which w...