BACKGROUND In many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies. Common examples include the nested case-control and the case-cohort designs. For two-phase studies, appropriate weighted survival estimates have been deriv...

In the analysis of competing risks data, cumulative incidence function is a useful summary of the overall crude risk for a failure type of interest. Mixture regression modeling has served as a natural approach to performing covariate analysis based on this quantity. However, existing mixture regression methods with competing risks data either impose parametric assumptions on the conditional ris...

OBJECTIVE Spondyloarthritis (SpA) is an extraintestinal manifestation of inflammatory bowel disease with significant clinical effects, although the frequency is uncertain. We assessed the cumulative incidence and clinical spectrum of SpA in patients with Crohn's disease (CD) in a population-based cohort. METHODS The medical records of a population-based cohort of Olmsted County, Minnesota, re...

BACKGROUND Heart transplantation (HTx), the gold standard therapy for advanced heart failure, is limited by donor availability; alternative therapies are now becoming available. AIM We examined the outcome of HTx with current immunosuppressive and adjunctive therapy. DESIGN AND METHODS We analysed the outcome of 399 consecutive patients who underwent transplantation at our centre (1995-2007...

BACKGROUND The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematological disease during childhood. METHODS We conducted a retrospective univer...

The risk factors for and incidence of central nervous system involvement at first relapse in adult patients with acute myeloid leukemia have not been established. This single-center study analyzed the prognostic factors for and cumulative incidence of meningeal relapse in 458 adult patients achieving complete remission. Before 1990, patients received old chemotherapy approaches without stem cel...

BACKGROUND Road traffic injuries (RTI) are a major public health epidemic killing thousands of people daily. Low and middle-income countries, such as Brazil, have the highest annual rates of road traffic fatalities. In order to improve road safety, this study mapped road traffic fatalities on a Brazilian highway to determine the main environmental factors affecting road traffic fatalities. ME...

Timely, accurate and reliable injury statistics are an important part of the public health approach to injury prevention. Unreliable statistics thwart efforts to monitor and respond to injury prevention and to assess the effectiveness of prevention initiatives. While most South Africans would concur that we have high incidences of injury and violence, official statistics do not explain the full...

In this paper, we introduce the concept of quantile-based generalized cumulative residual entropy of order $(alpha,beta)$ for residual and past lifetimes and study their properties. Further we study the proposed information measure for series and parallel system when random variable are untruncated or truncated in nature and some characterization results are presented. At the end, we study gene...