Nano fibrous membranes core-shell of poly(lactic acid) (PLA) and poly(?-caprolactone) (PCL), encapsulating 1 wt% curcumin, are fabricated by coaxial electrospinning technique. Morphology physical properties, as well the release studied compared with neat PLA PCL individually spinned. Morphological analysis shows for all samples obtainment fiber oriented in random way, without defect a narrow di...

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid...

In this work, we investigate the loading and conjugation of Curcumin on oleic acid (OA) and citric acid (CA) functionalized iron oxide nanoparticles and its applications in improving contrast in MRI. Magnetic iron oxide nanoparticles (Fe3O4, MNPs) synthesized using the co-precipitation method and characterized by XRD, DLS, FT-IR, VSM and SEM. FT-IR results confirmed functionalization with oleic...

Curcumin is proposed as a potential treatment option for coronavirus disease-19 (COVID-19) by inhibiting the virus entrance, encapsulation and replication, modulating various cellular signaling pathways. In this open-label nonrandomized clinical trial, efficacy of nano-curcumin oral formulation has been evaluated in hospitalized patients with mild–moderate COVID-19. Forty-one who fulfilled incl...

Onychomycosis is a disease of high incidence in the nail plate and responsible for approximately half of the cases of nail infections. Conventionally, dermatologists prescribe antibiotics and antifungals for long periods for its treatment. The high incidence of this type of infection and the increase of microbial strains resistant to the available drugs have justified the importance of the deve...

Curcumin, an aromatic phytoextract from the turmeric (Curcuma longa) rhizome, has been used for centuries for a variety of purposes, not the least of which is medicinal. A growing body of evidence suggests that curcumin has a broad range of potentially therapeutic pharmacological properties, including anti-inflammatory, anti-fibrotic, and anti-neoplastic effects, among others. Clinical applicat...

Sodium metabisulphite is used as an antioxidant agent in many pharmaceutical formulations. It is extensively used as a food preservative and disinfectant. It has been demonstrated that sulphite exposure can affect some organs. Curcumin, the main element of Curcuma longa, has been identified to have multiple protective properties. The present study extends the earlier works to quantitative evalu...

The present work was aimed with the objective of developing simple, precise and sensitive high performance liquid chromatographic method for simultaneous estimation quetiapine fumarate curcumin to execute developed in both drugs nanostructured lipid carrier formulations. carried out using various solvents, buffers, at different flow rates complete separation drugs. Using ICH guidelines, validat...