The BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative aims to produce a sophisticated understanding of the link between brain and behavior and to uncover new ways to treat, prevent and cure brain disorders.1 Success in meeting these multifaceted challenges will require scientific and technological paradigms that incorporate novel statistical methods for data acqui...

Some stochastic models for the copy number of plasmids in a cell line are studied. When considering the behavior of copy number in the whole cell line, the theory of multitype branching processes is appropriate. Attention is paid to the cure rate in the cell line, and the asymptotic fractions of cells containing a given number of plasmids. These quantities are used to compare the models numeric...

Behavioral problems are common in dementia and may reduce the quality of life of the patient and disrupt the home life of family members. Families want a pill that can cure the myriad phenotypes of a decaying brain; unfortunately, there is no pharmaceutical silver bullet. This paper reviews the evidence for using different classes of drugs for the behavior symptoms commonly encountered in demen...