We describe a case of cutaneous malignant melanoma metastatic to the iris as the first presenting sign of metastases 10 years after excision of the primary tumour. The histology of the excised iris metastases and the primary skin melanoma are compared. Progressive intracranial metastatic growth did not correlate with the observed regression of the residual intraocular melanoma cells during cycl...

Melanoma associated retinopathy is a rare paraneoplastic complication of metastatic cutaneous malignant melanoma. It may present years after the original diagnosis of melanoma. Here we describe a patient with this condition who presented with persistent photopsias and visual loss. We will discuss the electroretinographic findings and their utility.

Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in cancer, the prognostic signific...

A 79-year-old woman developed an orbital mass five and a half years after excision of a cutaneous melanoma from the side of the nose. The initial orbital biopsy was interpreted histopathologically as a malignant fibrous histiocytoma, but special stains and electron microscopy showed it to be a desmoplastic malignant melanoma which had apparently spread to the orbit from the prior skin lesion by...

In a retrospective review of 614 primary Stage I cutaneous malignant melanomata and 40 nonmelanoma lesions, the diagnostic accuracy(DA) for malignant melanoma was 86.2%. A positive preoperative clinical diagnosis of malignant melanoma was confirmed histologically in 564/604 (93.3%) of lesions. For 614 histologically proven malignant melanomata a correct pre-operative clinical diagnosis had been...

Small bowel tumors are very rare. Melanoma in small intestine can be primary or metastatic. Metastatic malignant melanoma arise from skin, eyes, oropharynx, esophagus ano rectal mucosa. Primary melanomas of In this case report, we going to present intestine, which has already metastasized by the time presentation. A 60 year old male, presented us with abdominal pain, vomiting and absolute const...

The incidence of cutaneous malignant melanoma, tumours arising from melanocytes, has increased markedly over the past few years in many countries. Although early melanoma is curable through surgical excision, the prognosis of advanced melanoma is very poor, this tumour being resistant to the current therapies. Thus, there is a need for new therapies to improve the treatment of advanced melanoma...

Primary malignant melanoma of the urinary bladder is a rare neoplasm, with only 19 cases reported to date. We present a case report of an 84-year-old woman who underwent transurethral resection of a mucosal melanoma of bladder origin. She had no previous or concurrent diagnosis of cutaneous melanoma. The patient underwent transurethral resection of the tumor 5 months before presentation at our ...

7 SAMMANFATTNING PÅ SVENSKA 9

Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spontaneous regression of the primary site could be an explanation. Case Report. We report a 58-year...