Genomic instability is characteristic of cancer cells, and promotes the accumulation of genetic lesions that contribute to their neoplastic progression. There are at least two general mechanisms by which cells exhibiting genomic instability can depart from the diploid state. One involves DNA damage from high levels of translocations, gene amplification or other chromosomal anomalies. The other ...

Nonlinear autonomous systems, often arise in different fields of science, are usually difficult to analyze. Pseudo linear representation of such systems recently has become very popular to deal with this difficulty. This paper presents a deep through analysis about the stability of nonlinear autonomous systems represented by pseudo linear forms. By discretization of the continuous-time dynamica...

The paper analyses the nature of limit cycles induced through the interaction of transformer tap changing and load dynamics. Linearization of a Poincaré map is used to prove local stability. An approximation is introduced which allows the map to be formulated explicitly. An estimate of the region of attraction can then be obtained.

Sister chromatid cohesion is mediated by cohesin, but the process of cohesion establishment during S-phase is still enigmatic. In mammalian cells, cohesin binding to chromatin is dynamic in G1, but becomes stabilized during S-phase. Whether the regulation of cohesin stability is integral to the process of cohesion establishment is unknown. Here, we provide evidence that fission yeast cohesin al...

This paper presents the gait generation and mechanical design of a humanoid robot based on a limit cycle walking method-Virtual Slope Control. This method is inspired by Passive Dynamic Walking. By shortening the swing leg, the robot walking on level ground can be considered as on a virtual slope. Parallel double crank mechanisms and elastic feet are introduced to the 5 DoF robot leg, to make t...

In this paper results are obtained concerning the number of positive stationary solutions in simple models of the Calvin cycle of photosynthesis and the stability of these solutions. It is proved that there are open sets of parameters in the model of Zhu et. al. [15] for which there exist two positive stationary solutions. There are never more than two isolated positive stationary solutions but...

The BRCA1 gene was isolated in 1994; germline mutations of this gene are known to confer susceptibility to breast and ovarian cancer in high-risk families. Since its discovery, several mutations have been identified in this gene; these are scattered throughout the gene, and include insertion and deletion frameshifts, base substitutions, and inferred regulatory mutations. It role in the pathogen...