Radiolabeled cyclic RGD peptides targeting integrin αvβ3 are reported as promising agents for the early diagnosis of metastatic tumors. With an aim to improve tumor uptake and retention of the peptide, cyclic RGD peptide dimer E[c (RGDfK)] 2 (E = Glutamic acid, f = phenyl alanine, K = lysine) coupled to the bifunctional chelator DOTA was custom synthesized and radiolabelled with Ga. Radiolabell...

In this chapter the expression “holonic cyclic manufacturing systems” refers to complex assembly/disassembly systems or fork/join systems, kanban systems, and in general, to any discrete event system that transforms raw material and/or components into products. Such a system is said to be cyclic if it provides the same sequence of products indefinitely. This chapter considers the scheduling of ...

To solve the problem of delivering pharmacologically promising 3ʹ,5ʹ-cyclic diadenosine monophosphate (cyclo-diAMP) to target cells in humans and animals, complexes above-mentioned dinucleotide with natural polymer – chitosan were originally synthesized by ionotropic gelation technique. It was found that binding degree cyclo-diAMP this biopolymeric carrier reaches 60 %; wherein capacity obtaine...

Protein kinases catalyze the transfer of the terminal phosphate of ATP to a variety of acceptor proteins [ 11. It has been demonstrated that cyclic adenosine 3’, 5’-monophosphate (cyclic AMP) activates protein kinase (holoenzyme, RC) by forming a complex with the regulatory subunit (R) to release the catalytic subunit (C) in the active state [2,3]. In a previous communication from this laborato...

Cyclic guanosine 3',5'-monophosphate (cyclic GMP) is a second messenger whose role in bacterial signalling is poorly understood. A genetic screen in the plant pathogen Xanthomonas campestris (Xcc) identified that XC_0250, which encodes a protein with a class III nucleotidyl cyclase domain, is required for cyclic GMP synthesis. Purified XC_0250 was active in cyclic GMP synthesis in vitro. The li...

Key points • Expressed by the physiological phasic events of NREM sleep, including arousals, cyclic alternating pattern represents the most complex arrangement of sleep microstructure. • Cyclic alternating pattern is organized in sequences organized in successive cycles. Each cyclic alternating pattern cycle is composed of a phase A (phasic events) and a phase B (background rhythm). • Cyclic al...

this paper presents the results of a series of monotonic and post-cyclic triaxial tests carried out on a clay specimen and three types of clay-sand mixed specimens. the focus of the paper is on the post-cyclic mechanical behavior of the mixed specimens, as compared to their monotonic behavior. analyses of the tests results show that cyclic loading degrade undrained shear strength and deformatio...