Tensile test data for structural steels are ubiquitous. However, the information monotonic loading provides with respect to material’s characteristics is limited. Notably, features of inelastic response cyclic loading, such as Bauschinger effect, cannot be determined without testing a load reversal protocol. This study aimed at addressing this shortcoming by formulating constrained optimization...

Background: Nickel-based superalloys are usually exposed to high static or cyclic loads in non-ambient environment, so a reliable prediction of their mechanical properties, especially plastic deformation, at elevated temperature is essential for improved damage-tolerance assessment of components. Methods: In this paper, plastic deformation in a single-crystal nickel-based superalloy CMSX4 at el...

BACKGROUND AND PURPOSE Advanced age is associated with a decrease in brain plasticity compared with the young adult. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor promotes brain plasticity and improves functional outcome after stroke in the young animal. Here, we test the hypothesis that sildenafil provides restorative therapeutic benefit to the aged animal. METHODS Male Wistar rats...

Silver nanowires are promising components of flexible electronics such as interconnects and touch displays. Despite the expected cyclic loading in these applications, characterization of the cyclic mechanical behavior of chemically synthesized high-quality nanowires has not been reported. Here, we combine in situ TEM tensile tests and atomistic simulations to characterize the cyclic stress-stra...

The evolution of language has been the subject of much debate and speculation. It is difficult to study in a scientific manner and remains an open research question. This paper proposes an integrated computational framework for investigating possible scenarios of genetic and cultural evolution of language. Specifically, our framework aims to capture cultural evolution to allow for investigation...

Loss-of-function mutations in the gene encoding for the RhoGAP protein of oligophrenin-1 (OPHN1) lead to cognitive disabilities (CDs) in humans, yet the underlying mechanisms are not known. Here, we show that in mice constitutive lack of Ophn1 is associated with dysregulation of the cyclic adenosine monophosphate/phosphate kinase A (cAMP/PKA) signalling pathway in a brain-area-specific manner. ...

This paper describes high temperature cyclic elastic-plastic testing of XN40F material for application to the life prediction of superplastic forming (SPF) tools. Cyclic plasticity material constitutive constants are identified from the high temperature tests across the range of 20C to 900C for representative predicted die conditions. These material constants are implemented within a transient,...