In the last decades many efforts have been devoted to design supramolecular organocatalysts able to work in water as the reaction medium. The use of water as solvent provides promising benefits with respect to environmental impact. In this context, macrocyclic compounds played a role of primary importance thanks to their ease of synthesis and their molecular recognition abilities toward the rea...

Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine, industry and basic sciences owing to their ability to solubilize and stabilize guest compounds. In medicine, cyclodextrins primarily act as a complexing vehicle and consequently serve as powerful drug delivery agents. Recently, uncomplexed cyclodextrins have emerged as potent therapeutic compounds in their ...

The alternative for a pure soluble, sensible for physical and chemical conditions oil form of α-tocopherol (α-T) is its complexation with cyclodextrins. A different influence of cyclodextrins on the included substance demands a stability investigation of the substance enclosed in a host-guest complex. Hence, the thermal stability of α-T in inclusion complexes (InCs) with cyclodextrins (CDs) was...

Galanin-like peptide (GALP) shows potential as a therapeutic in the treatment of obesity and related conditions. In this study, we compared the uptake by brain regions and peripheral tissues of radioactively iodinated GALP (I-GALP) after intranasal (i.n.), i.v., and i.c.v. administration. I-GALP was stable in blood and brain during the 10-min study time regardless of route of administration, an...

In this work the enhancing effect of cyclodextrins on the buccal permeation of a hydrophobic model drug, omeprazole was studied. First, the influence of the complexation with cyclodextrins in the absence and in the presence of an alkali agent, L-arginine, on the drug stability was checked at neutral conditions since omeprazole alone is only stable in basic conditions. In vitro transbuccal perme...

A continuous process of hydroaminomethylation in an aqueous multiphase system utilizing the green mass transfer agents randomly-methylated-β-cyclodextrins was established.

Cyclodextrins act as growth controllers in the synthesis of PVP-stabilized Ru(0) nanoparticles, leading to enhancement of the catalytic activity in the hydrogenation of furfural.

Stereochemical outcomes were critically tuned by excitation wavelength in the supramolecular photocyclodimerization of 2-anthracenecarboxylic acid mediated by native and diamino-modified γ-cyclodextrins.

A novel water-soluble nanorod is discussed, which is prepared via the self-assembly of pristine C60 and a double-sided porphyrin projecting four beta-cyclodextrins from each face.

background: we aimed to compare clinical effects of sugammadex versus combination of anticholinergic-anticholinesterase agents for reversing of nondepolarizing neuromuscular block in pediatric patients.materials and methods: a total of 60 pediatric patients  whom should be performed general anesthesia in the supine position were enrolled to this randomized double-blinded clinical trial.fentanyl...