نتایج جستجو برای: cyclooxygenase
تعداد نتایج: 15217 فیلتر نتایج به سال:
OBJECTIVE Both vascular endothelial growth factor and cyclooxygenase 2 overexpression have been associated with poor prognosis in a variety of human malignancies. In this study we assessed the effect of preoperative chemotherapy and radiation on expression levels of vascular endothelial growth factor and cyclooxygenase 2 in patients with esophageal cancer and determined whether these markers we...
Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...
In this study, we focused on screening and simulating the interaction between anti-inflammatory proteins 50 compounds isolated from Millettia dielsiana Harms ex Diels. 39 out of that violated no Lipinski’s rule five were sorted as favorable for drug development selected studies further. Then, a molecular docking study into binding sites COX-1 COX-2 allowed shedding light mode these potential CO...
BACKGROUND A low circulating vitamin B-6 concentration, which is an independent risk factor for cardiovascular disease, is commonly seen in human inflammation. OBJECTIVE We investigated whether cyclooxygenase inhibitors alter vitamin B-6 metabolism. DESIGN To investigate whether subjects taking a cyclooxygenase inhibitor had an altered vitamin B-6 profile, we conducted a cross-sectional stu...
High levels of NaCN (20 to 250 mM) were required to inhibit cyclooxygenase catalysis and cause extended lag periods (up to 1.6 min), whereas CO failed to inhibit catalysis. This NaCN inhibition was easily overcome by endogenous or exogenous hydroperoxides. Added hydroperoxides acted to eliminate lag periods without undergoing net conversion to other chemical species. In addition, experiments wi...
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