نتایج جستجو برای: cyp2c19 polymorphism

تعداد نتایج: 108891  

2012
Rolf P Kreutz Perry Nystrom Yvonne Kreutz Jia Miao Zeruesenay Desta Jeffrey A Breall Lang Li ChienWei Chiang Richard Kovacs David A Flockhart Yan Jin

BACKGROUND The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite. Conflicting results have been reported in regard to (1) the association of a common polymorphism of PON1 (Q192R) with reduced rates of coronary stent thrombosis in patients takin...

2011
Kyoung-Jin Park Hae-Sun Chung Suk-Ran Kim Hee-Jin Kim Ju-Yong Han Soo-Youn Lee

BACKGROUND Clopidogrel has been widely used to prevent recurrent ischemia in patients with acute coronary syndrome (ACS). However, inter-individual variability in response to clopidogrel has been a problem in the clinical setting. The aim of the present study was to investigate the frequency of clopidogrel resistance and to determine the clinical, pharmacokinetic, and pharmacogenetic factors fo...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2001
K Kosuge Y Jun H Watanabe M Kimura M Nishimoto T Ishizaki K Ohashi

Diazepam is metabolized by CYP2C19 and CYP3A4 in the liver. CYP2C19 shows genetic polymorphism associated with the poor metabolizer (PM) and extensive metabolizer (EM) phenotypes. The aim of this study was to assess the effect of diltiazem, a CYP3A4 inhibitor, on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Thirteen healthy volunteers (eight EMs and five PMs...

Journal: :Croatian medical journal 2003
Nada Bozina Paula Granić Zdenka Lalić Inja Tramisak Mila Lovrić Ana Stavljenić-Rukavina

AIM To determine the prevalence of most common mutations of cytochrome P450 (CYP), ie, allelic variants of CYP2C9, CYP2C19, and CYP2D6, and to predict genotype frequency in the Croatian population. METHODS CYP genotype was determined in 200 non-related Croatian citizens. DNA isolated from blood samples was used for the analysis of the most common allelic variants of CYP2C9, CYP2C19, and CYP2D...

2016
Xiang-Long Liu Qiu-Ju Jia Li-Na Wang Zong-Ming Liu Hai Liu Xuan-Chu Duan Xue-Man Lyu

BACKGROUND The aim of this study was to investigate the roles of cytochrome P450 2C19 (CYP2C19) polymorphisms in primary open-angle glaucoma (POAG) susceptibility and individual responses to drug treatment. MATERIAL/METHODS This case-control study consisted of 93 cases with POAG and 125 controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze...

Journal: :research in molecular medicine 0
بهزاد پوپک behzad poopak khaghani st, shariati ave , tehran, iran مائد حیدری maed heidari khaghani st, shariati ave , tehran, iran پرویز فلاح parviz fallah alborz university of medical sciences, alborz, iran نازیلا صفری nazila safari no 174, zafar st., shariati ave., tehran, iran ساغر ربیعی پور saghar rabieipoor no 174, zafar st., shariati ave., tehran, iran زهرا امیری zahra amiri tehran medical branch, islamic azad university. tehran, iran شهرام تقدیسی

background: clopidogrel is a standout amongst the most ordinarily recommended medications to avoid ischemic occasions taking after coronary disorder or stant position. however, impaired responses the therapy as well as resistance to the therapy have also been reported. genetic variants play an important role in clopidogrel biotransformation of its active metabolite that may subsequently influen...

2017
Eric Rytkin Karin B Mirzaev Elena A Grishina Valeriy V Smirnov Kristina A Ryzhikova Zhannet A Sozaeva Michael Iu Giliarov Denis A Andreev Dmitriy A Sychev

AIM The aim of this study was to determine the impact of CYP2C19 and ABCB1 gene polymorphisms and CYP3A4 isoenzyme activity on stent implantation complications among patients with an acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). PATIENTS AND METHODS Seventy-six patients (median age 63, range 37-91 years) with an ACS who underwent PCI were screened for C...

Journal: :Medicina 2014
Gustavs Latkovskis Inga Urtane Agnese Knipse Raitis Peculis Inese Cakstina Janis Klovins Andrejs Erglis

BACKGROUND AND OBJECTIVE Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy. MATERIALS AND METHODS We enrolled 118 patients undergoing elective or acute percutaneous coronar...

Journal: :European heart journal 2011
Dirk Sibbing Werner Koch Steffen Massberg Robert A Byrne Julinda Mehilli Stefanie Schulz Katharina Mayer Isabell Bernlochner Albert Schömig Adnan Kastrati

AIMS In clopidogrel-treated patients undergoing coronary stenting, high on-treatment platelet reactivity was linked to a higher risk of stent thrombosis (ST). Platelet response to clopidogrel is significantly influenced by genetic factors. Recently published findings showed a highly significant impact of a common polymorphism (Q192R) within the paraoxonase-1 (PON1) gene on clopidogrel treatment...

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