BACKGROUND Several markers are available to estimate the glomerular filtration rate (GFR) in patients. Cystatin C is a relatively new marker and has been suggested as an alternative for creatinine. Numerous studies have been performed to evaluate the usefulness of cystatin C to estimate GFR. The aim of this study is to compare the renal extraction of cystatin C with that of 125I-iothalamate in ...

BACKGROUND Contrast-induced nephropathy (CIN) frequently complicates cardiac catheterization, so the objectives of present study were to investigate the usefulness of cystatin C before catheterization and establish a cut-off level for CIN, and to examine the changes in cystatin C and several other markers in patients with and without CIN. METHODS AND RESULTS Prospective study of consecutive 8...

Objective: To investigate the association between serum cystatin C and vascular endothelial function in patients with essential hypertension. Methods: A total of 434 cases (male 228, female 206) with an average age of (56.5±12.0) years were enrolled in the first hospital of Shanxi Medical University, including 343 patients with essential hypertension and 100 patients without hypertension, rangi...

Leucocyte elastase in catalytic amounts was observed to rapidly cleave the Val-10-Gly-11 bond of the human cysteine-proteinase inhibitor cystatin C at neutral pH. The resulting modified inhibitor had size and amino acid composition consistent with a cystatin C molecule devoid of the N-terminal Ser-1-Val-10 decapeptide. Leucocyte-elastase-modified cystatin C had more than 240-fold lower affinity...

BACKGROUND In chronic human immunodeficiency virus (HIV) infection, plasma cystatin C may be influenced by factors other than glomerular filtration rate such as inflammation. Statins may improve cystatin C by improving glomerular function or by decreasing inflammation. METHODS The Stopping Atherosclerosis and Treating Unhealthy Bone With Rosuvastatin in HIV (SATURN-HIV) trial randomized 147 p...

OBJECTIVE Cystatin C is growing to be an ideal indicator for renal function and cardiovascular events. The aim of this study was to investigate the relationship between serum cystatin C levels and peripheral arterial disease and to explore its diagnostic value for lower limb ischemia (LLI) in type 2 diabetic population. METHODS A total of 1609 T2DM patients were included in this cross-section...

Because all the patients had chronic kidney disease (CKD) (GFR <55 mL/min per 1.73 m 2 ), this study cannot be used to assert that cystatin C is definitively better than creatinine for detecting stage 3 kidney disease (GFR <60 mL/min per 1.73 m 2 ). Regarding the study methods, the authors do not mention when cystatin C was measured in the frozen samples. Were the samples measured retrospective...

UNLABELLED Serum cystatin C concentration, generally accepted as renal function marker, is associated with cardiovascular risk and metabolic syndrome. Recent studies indicate that cystatin C increases in human obesity and that adipose tissue contributes to enhanced serum cystatin C concentration in obese subjects. The aim of the study was to assess whether a reduction in body and fat mass after...

BACKGROUND Serum cystatin C level is a more sensitive marker of renal dysfunction than serum creatinine level. Serum cystatin C level was recently reported to predict the development of cardiovascular disease. This study was performed to evaluate whether the cystatin C level is associated with coronary artery disease (CAD), independent of diabetic nephropathy. METHODS We conducted a case-cont...