BACKGROUND/AIMS Clinicopathological investigation of the indications for the use of endoscopic papillectomy as a treatment for carcinoma in situ of the ampulla of Vater (CAV). MATERIALS AND METHODS Of 97 patients diagnosed with CAV in our department over the last 15 years, the 5 patients who received a carcinoma in situ diagnosis and were included in this retrospective study. RESULTS The le...

OBJECTIVES Carcinoma of unknown primary origin (CUP) is heterogeneous group of cancers. Role of gastrointestinal (GI) endoscopy in this entity is under investigated. Aim of this study was to evaluate yield of Colonoscopy and Esophagogastroduodenoscopy (EGD) in localizing primary tumor in patients with CUP. METHODOLOGY Patients with histopathologically proven CUP who underwent colonoscopy / EG...

During meiotic maturation, the cortical cytokeratin filament system of the Xenopus oocyte disappears (Klymkowsky, M. W., and L. A. Maynell. 1989. Dev. Biol. 134:479). Here we demonstrate that this disappearance results from the severing of cytokeratin filaments into a heterogenous population of oligomers, with S- values ranging from 12S and greater. Cytokeratin filament severing correlates with...

We have used whole-mount immunofluorescence microscopy of late-stage Xenopus laevis oocytes and early embryos to examine the organization of their cortical cytokeratin systems. In both mature oocytes and early embryos, there is a distinct animal-vegetal polarity in cytokeratin organization. In mature (stage-VI) oocytes, the cytokeratin filaments of the vegetal region form a unique, almost geode...

BACKGROUND Clear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies. CASE PRESENTATION ...

of the pancreas is extremely rare [1]; only three cases have been reported in the literature [2–4]. A61-year-oldmanpresentedwith abdominal pain. Laboratory blood testing revealed hyperamylasemia (626 IU/L). Tumor marker concentrations were within normal ranges. Upper gastrointestinal endoscopy showed no significant changes, as did CT including the pancreas. Pancreatitis was suspected and the pa...

microRNAs are thought to regulate tumor progression and invasion via direct interaction with target genes within cells. Here the microRNA17/20 cluster is shown to govern cellular migration and invasion of nearby cells via heterotypic secreted signals. microRNA17/20 abundance is reduced in highly invasive breast cancer cell lines and node-positive breast cancer specimens. Cell-conditioned medium...

of the pancreas is extremely rare [1]; only three cases have been reported in the literature [2–4]. A61-year-oldmanpresentedwith abdominal pain. Laboratory blood testing revealed hyperamylasemia (626 IU/L). Tumor marker concentrations were within normal ranges. Upper gastrointestinal endoscopy showed no significant changes, as did CT including the pancreas. Pancreatitis was suspected and the pa...

BACKGROUND Myxopapillary ependymomas (MPE) occur in the filum terminale of the spinal cord, but also present in extra-spinal locations such as subcutaneous tissue and brain. They are slow growing grade I gliomas. Areas of solid growth pattern with aggregates of cells with "epithelioid morphology" seen in MPE can mimic metastatic carcinoma. The presence of occasional cells with clear cytoplasm a...

Colorectal cancer (CRC) is the second most prevalent cause of cancer-related deaths in the Western world. 5-Fluorouracil (5-FU) is a standard chemotherapeutic drug to treat CRC. However, the response rate is less than 20% and patients who have responded to 5-FU may become resistant. Therefore there is an urgent need to examine the 5-FU response proteins so that patients with no response to 5-FU...