Objective: This work aimed of to review the implications anti-TNF-α therapy in COVID-19 patients associated with genetic polymorphism (TNF-α polymorphisms region-308) this pertinent cytokine Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web Science and The Cochrane Library aid key-words. Results: Twenty-six articles collected. Anti-TNF-α was interpreted evalua...

BACKGROUND Tumor necrosis factor-alpha (TNF-α) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-α gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-α-23...

background: gastric cancer (gc) is one of the most commonly diagnosed malignancies. genetic variation in genes encoding cytokines and their receptors, determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. interleukin-10 (il-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic f...

PURPOSE Interleukin-6 (IL-6) encodes a cytokine protein, which causes inflammation, maintains immune homeostasis and plays an essential role in oral pathogenesis. The aim of this study was to evaluate the association between IL-6 (- 174 and - 572) G/C promoter gene polymorphisms and risk of OSCC among Indians. METHODS Single nucleotide polymorphism in IL-6 genes was genotyped in OSCC patients...

It is known that interleukin-18 (IL-18) is a proinflammatory cytokine with dual effects on tumor development and progression. It can increase the immune defense against tumor cells. Polymorphisms in the IL-18 genes are known to influence both expression levels and may be associated with outcome of cancers. This study was aimed to find out the possible ass...