ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping researchers promote themselves alongside their papers. Stephen Coscia author on ‘ Myo19 tethers mitochondria to endoplasmic reticulum-associated actin mitochondrial fission’, JCS. PhD student lab Dr Erika Holzbaur at University Pennsylvania, where he uses microscopy...

The actin cytoskeleton is a highly dynamic system responsible for maintaining cell shape and rigidity. In endothelial cells, the actin cytoskeleton undergoes a remarkable reorganization in response to shear at the cell surface. This rearrangement likely occurs through regulation of cytoskeletal dynamics. This thesis presents a viable technology for the measurement of two fundamental dynamic pro...

We propose a model to explain finite-size effects in intracellular microrheology observed in experiments. The constrained dynamics of the particles in the intracellular medium, treated as a viscoelastic medium, is described by means of a diffusion equation in which interactions of the particles with the cytoskeleton are modelled by a harmonic force. The model reproduces the observed power-law b...

Objective: The deformation ability of erythrocytes is critical for their function and affects mobility in the circulation. To circulate travel through narrow vessels, must continuously alter shape by modifying cytoskeleton, which controls elasticity stability. Erythrocytes lack nuclei other major organelles, thus most known signaling cascades are thought to be inactive these cells. As noncanoni...

ARTICLE HISTORY Received 19 July 2017 Revised 12 September 2017 Accepted 13 September 2017 ABSTRACT Bin-Amphiphysin-Rvs (BAR) domain containing proteins with their membrane deforming properties have emerged as key players in shaping up neuronal morphology and regulating cytoskeletal dynamics. However, the in vivo contexts in which BAR-domain proteins integrate membrane dynamics with cytoskeleta...

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. When expressed in tumours, SNPH inhibits the spe...

Colonic paracellular permeability is regulated by various factors, including dynamics of the cytoskeleton. Recently, ACF7 has been found to play a critical role in cytoskeletal dynamics as an essential integrator. To elucidate the physiological importance of ACF7 and paracellular permeability, we conditionally knocked out ACF7 in the intestinal mucosa of mice. Histopathological findings indicat...

A theory for diffusivity estimation spatially extended activator-inhibitor dynamics modelling the evolution of intracellular signaling networks is developed in mathematical framework stochastic reaction-diffusion systems. In order to account model uncertainties, we extend results parameter semilinear partial differential equations, as [PS20], problem joint and parametrized reaction terms. Our t...

microtubule affinity-regulating kinase 2 (mark2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. the abnormal function of this protein has been associated with a number of pathological conditions like alzheimer disease, autism, several carcinomas and development of...

Cytoskeleton remodeling can be regulated, among other mechanisms, by lysine acetylation. The role of acetylation on cytoskeletal and other proteins of Entamoeba histolytica has been poorly studied. Dynamic rearrangements of the actin cytoskeleton are crucial for amebic motility and capping formation, processes that may be effective means of evading the host immune response. Here we report the p...