objective(s):valproic acid (vpa), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. a relation between telomerase activity and resistance to apoptosis has been established. t...

Background: Polysaccharides have long been used as immune-modulators in various pathologic conditions including inflammation and solid malignancies. Objective: To evaluate the effects of Zymosan and Betaglucan on cytotoxic reactions in an effectortarget conjugate system. Methods: Blood was obtained from 20 healthy subjects; purified mononuclear leukocytes (monocytes and lymphocytes) were extrac...

Background: Dorema aucheri (Apiaceae) grows in west and southwest of Iran. Young leaves of this plant are used orally as pickle or for cooking some local foods, as well as for the treatment of parasitic digestive infections and constipation. Objective: The aim of present study was evaluation of cytotoxic potential and total phenols determination of D. aucheri young aerial parts extract and fr...

EVALUATION OF THE EFFECTS IBUPROFEN CYTOTOXIC DOSE ON EXPRESSION LEVEL EXTRACELLULAR MATRIX DEGRADING MMP-9 AND ANTI-METASTASIS NM23 GENES IN CERVICAL CANCER CELLS

several attempts have so far been made in the search of new anticancer agents of plant origin. some studies have reported that different species of pine genus possess cytotoxic activities against various cancer cell lines. in the present study, we evaluated the cytotoxic effects of pinus eldarica bark and leaf extracts or leaf essential oil on hela and mcf-7 tumor cell lines. hydroalcoholic and...

Ferula communis L., subsp. communis, namely giant fennel, has extensively been used in traditional medicine for a wide range of ailments. Fresh plant materials, crude extracts and isolated components of F. communis showed a wide spectrum of in vitro and in vivo pharmacological properties including antidiabetic, antimicrobial, antiproliferative, and cytotoxic activities. The present paper, revie...

Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and th...

nowadays, growing interest in the application of nanotechnology in biomedical and biotechnological fields has opened a new avenue to explore the nanoparticles-biological system interaction. indeed, a clear gap is still in the cytotoxic effect of nps on the biological systems. for this purpose, the interaction of the silica oxide nanoparticles (sio2-np) with pc12 cell line, as a model of nervous...

conclusions as l. crispatus and l. jensenni were significantly higher in bv infected women and the cytotoxic effect of l. crispatus on tumoral cervical cells was high, introduction of new probiotics seems necessary. results l. crispatus, l. gasseri, l. iners, l. jensenii, l. acidophilus and l. rhamnosus were the most frequently occurring species in vagina of healthy iranian women. l. crispatus ...