Leptospira spp., the causative agents of leptospirosis, adhere to components of the extracellular matrix, a pivotal role for colonization of host tissues during infection. Previously, we and others have shown that Leptospira immunoglobulin-like proteins (Lig) of Leptospira spp. bind to fibronectin, laminin, collagen, and fibrinogen. In this study, we report that Leptospira can be immobilized by...

METHODS. Subjects were designated as having mild, moderate, or severe AD based on SCORing Atopic Dermatitis index. Skin prick testing and specific immunoglobulin E testing to foods and aeroallergens allergens were used to determine allergic sensitization. Peripheral eosinophil counts, 25-hydroxy vitamin D levels, and total immunoglobulin E were measured. Patients were grouped according to aller...

Abstract Maternal antibody-mediated fetal red blood cell destruction secondary to non-D Rh system antibodies is a significant cause of hemolytic disease the fetus and newborn. Here, we report rare case severe perinatal associated with maternal antibody e antigen. In addition anemia, infant developed hyperbilirubinemia. Resolution infant’s anemia hyperbilirubinemia occurred after treatment photo...

BrMedj 1989;298:1671-3 Abstract Objective-To measure the safety and efficacy of antenatal treatment with anti-D immunoglobulin. Design-Open study with historical controls. Setting-Multicentre study in 17 hospitals in West Yorkshire. Patients-1238 Rh negative women who delivered Rh positive infants after 34 weeks in their first pregnancy in 1980-1 (group 1) and 2000 similar primigravidas from 19...

The pre-B cell receptor is a key checkpoint regulator in developing B cells. Early events that are controlled by the pre-B cell receptor include positive selection for cells express membrane immunoglobulin heavy chains and negative selection against cells expressing truncated immunoglobulins that lack a complete variable region (D mu). Positive selection is known to be mediated by membrane immu...

Introduction While the use of elevated middle cerebral artery peak systolic velocity (MCA PSV) in assessing fetal anaemia is well known, its occurrence is uncommon due to the current practice of giving prophylactic doses of ultrafiltered Rh (D) immunoglobulin (anti-D) in Rh (D) negative women. In mothers who do not receive prophylaxis with Rh immunoglobulin, the overall risk of immunisation for...