LEKTI is a 15-domain serine proteinase inhibitor whose defective expression underlies the severe autosomal recessive ichthyosiform skin disease, Netherton syndrome. Here, we show that LEKTI is produced as a precursor rapidly cleaved by furin, generating a variety of single or multidomain LEKTI fragments secreted in cultured keratinocytes and in the epidermis. The identity of these biological fr...

In 1955, Herbert Simon introduced the notion of satisficing: an agent satisfices by searching for alternative that meets aspiration level but does not optimize. We survey more than 60 years advances in understanding satisficing economics, psychology, and management, identifying two research traditions address classes situations: under risk, is typically inferior to optimization strategies model...

This paper computes optimal top marginal tax rates in Bewley-Huggett-Aiyagari–type economies that include entrepreneurs. Consistent with the data, entrepreneurs are overrepresented at of income distribution and thus disproportionately affected by an increase rate. The rate maximizes welfare is 60 percent. While average gains positive similar across occupations along transition, they larger for ...

We study fairness in economies where humans consume one private good and public representing the welfare of other species. show that a social evaluator cannot be egalitarian with respect to while always respecting humans’ unanimous preferences. One solution is preferences only when doing so does not lead decrease Social satisfying these properties reveal surprising connections between concerns ...

Enfant âgé de 12 ans, sans antécédents pathologiques notables, est admis aux urgences pour une paraparésie évoluant depuis 23 jours. L'interrogatoire a révélé la présence de troubles sphinctériens et l'examen clinique a mis en évidence des reflexes ostéo-tendineux abolis avec un tonus flasque et un déficit sensitivomoteur bilatéral. L'imagerie par résonnance magnétique a montré la présence d'im...

As part of a systematic study of the spine between D11 and S1 the response to stress has been assessed by measuring radiologically the total and segmental mobility of 103 specimens. The method was shown to be reproducible to within 10% of total mobility. No significant sex difference was seen. Total mobility varied widely, but mean total mobility fell with age. All lumbar segments became less m...

Of 93 strains of Staphylococcus aureus isolated from inpatient wards of Ismailia General Hospital, 48 (51%) were proven to be methicillin resistant (MR). Of these MR S. aureus strains, 44 were isolated from patients and 4 were isolated from healthy carriers, who were newly arrived interns working in the same wards. Bacteriophage patterns of MR S. aureus were identified by using routine test dil...

CLC chloride channels form a large and conserved gene family unrelated to other channel proteins. Knowledge of the transmembrane topology of these channels is important for understanding the effects of mutations found in human myotonia and inherited hypercalciuric kidney stone diseases and for the interpretation of structure-function studies. We now systematically study the topology of human Cl...

Eleven diets (D1-D11), designated as treatments (T1-T11), supplemented with different levels of inorganic phosphorus (P) (Ca2PO4) were fed to Heterobranchus bidorsalis (10.8 ±0.02 g) to determine the optimum P requirement. D1 D11 contained total P of 10.2, 10.4, 11.0, 11.9, 12.3, 12.6, 13.4, 13.9, 14.2 14.7 and 15.4 g kg respectively. After 84 days of feeding trial, there was increase in fish g...

We study a dynamic equilibrium search model where sellers differ in their urgency to liquidate an asset. Buyers strategically make price offers without knowing given seller’s urgency. liquidity and dynamics on the transition path after unexpected shock. Generically, includes phase all buyers offer same price, causing market collapse; however, dispersion resumes finite time, leading recovery bot...