Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2- to 3-fold increase in the number of DNA mutations in the hematopoietic system upon aging. Young and aged hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) do not show an increase in mutation u...

A three-phase model is presented that predicts solid deformation and damage as well as melt pressure, feeding flow and shrinkage porosity during metal casting. A visco-plastic constitutive theory with damage is used to model the solid deformation. Damage created by mechanically induced voiding is used as a hot tear indicator. The absence of liquid feeding determines when damage starts to form. ...

Damage detection in civil engineering structures using changes in measured modal parameters is an area of research that has received notable attention in literature in recent years. In this paper two different experimental techniques for predicting damage location and severity have been considered: the Change in Mode Shapes Method and the Mode Shapes Curvature Method. The techniques have been a...

This paper presents some aspects related to the issues of aggregating economic indicators. Departing from the research of Gh. Paun (1983) we will prove a theorem which states that under certain, natural assumptions, it is impossible to obtain an optimum aggregation. Unlike the original work of Paun, in this paper we are giving a rather simple proof of this theorem.

The validity of the Michaelis-Menten-Briggs-Haldane approximation for single enzyme reactions has recently been improved by the formalism of the total quasi-steady-state approximation. This approach is here extended to fully competitive systems, and a criterion for its validity is provided. We show that it extends the Michaelis-Menten-Briggs-Haldane approximation for such systems for a wide ran...

In December 2003, seventeen years after the first UK research assessment exercise, Italy started up its first-ever national research evaluation, with the aim to evaluate, using the peer review method, the excellence of the national research production. The evaluation involved 20 disciplinary areas, 102 research structures, 18,500 research products and 6,661 peer reviewers (1,465 from abroad); i...

Ameisen: Die heimliche Weltmacht (Ants: Nature's Secret Power) is a nature documentary about ants. Wolfgang Thaler wrote, filmed, and directed the film, which focuses on the work of ant researcher Bert Hölldobler. The 2004 film was produced by Adi Mayer Film for Österreichischer Rundfunk (Austrian Broadcasting), a public service broadcaster headquartered in Vienna, Austria. Ants: Nature's Secre...

We construct a hybrid, economic indicator of the sustainability of global well-being, which is more inclusive than existing indicators and incorporates an environmentally pessimistic, physical constraint on global warming. Our methodology extends the World Bank’s Adjusted Net Saving (ANS) indicator to include the cost of population growth, the benefit of technical progress, and a much higher, p...

The monitoring of rotating machinery is increasingly important for industry. Partly, it is made from indicators given by vibration analysis. These indicators give only the overall state of operation of the studied machine. Indeed, the piezoelectric sensors, which are used for vibration analysis, record the vibrations generated by the various components of the machine. Numerous studies have deve...

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