Background/Aim: Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics mammary carcinomas induced by neutrons. Materials and Methods: Mammary obtained female Sprague-Dawley rats irradiated at 7 weeks age with 0.97 Gy neutrons or 4 ?-rays non-irradiated were classified into luminal non-luminal subtypes immunohistochemistry. Their mutational land...

Gastroenterology Medicine & Research Evaluation of Disease Index, Colon Damage Score, and Microbial Analysis Intestinal Flora after Treatment with the Novel Test Formulation in TNBS-Induced Colitis Sprague Dawley Rats Mahendra Kumar Trivedi1 Snehasis Jana2* 1Trivedi Global, Inc, Henderson, Nevada, USA 2Trivedi Science Laboratory Pvt. Ltd., Thane-West, Maharashtra, India *Corresponding author:Sn...

Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The aim of this work was to establish and characterize a nutritional model of NAFLD in rats. Wistar or Sprague-Dawley male rats were fed ad libitum a standard diet (ST-1, 10 % kcal fat), a medium-fat gelled diet (MFGD, 35 % kcal fat) and a high-fat gelled diet (HFGD, 71 % kcal fat) for 3 or...

Due to a large number of mutations in the spike protein and immune escape, Omicron variant (B.1.1.529) has become predominant concern (VOC) strain. To prevent disease, we developed candidate inactivated vaccine (Omicron COVID-19 Vaccine (Vero Cell), Inactivated). evaluate safety vaccine, tested repeat-dose toxicity Sprague-Dawley (SD) rats. The doses were administered randomly three groups: phy...

The pancreas plays an important role in the homeostasis of zinc (Zn), a nutritionally essential metal. In several previous studies, Zn ions induced inflammatory changes exocrine pancreas; however, little is known about complexes. this study, we microscopically, immunohistochemically, and ultrastructurally examined pancreatic lesions Sprague-Dawley (SD) rats by 4-week repeated oral dose toxicity...

Annona muricata L. (Annonaceae) is widely used in the Amazon and Carribean natural medicine as an antiparasitic, insecticidal, sedative astringent for diarrhea among others. In Nigeria however, under-utilized species of plants. This study investigated antidepressant ambulatory effect A. muricata, using open field test forced swim tests on Sprague-Dawley rats administered ethanol stem-bark extra...

Ketamine is widely used in veterinary medicine and in medicine. Ketamine is metabolized to its active metabolite norketamine principally by liver CYP3A. Drug metabolism alterations during aging have severe consequences particularly in anesthesiology and very few studies on older animals were conducted for ketamine. The objective of the present study is to assess the influence of aging on CYP3A ...

Four strains of rats were each infected intrabronchially with approximately 10(8) CFU of Bordetella pertussis 18-323 encased in fine agarose beads. After 8 days, Sprague-Dawley rats developed the highest incidence of coughing paroxysms, as monitored with voice-activated tape recorders; Brown Norway, Lewis, and Hooded Lister rats coughed significantly less frequently. Marked leukocytosis, with c...

In the signal attenuation rat model of obsessive-compulsive disorder, 'compulsive' behavior is induced by attenuating a signal indicating that a lever-press response was effective in producing food. In recent years several studies have reported that Lewis rats, an inbred strain derived from the Sprague Dawley strain, exhibit addictive and/or compulsive tendencies. The aim of the present study w...

Rats frequently develop various tumors, many of them malignant; the majority of tumors in the females develop in the mammary glands. In primary spontaneous tumors and lymphomas virus particles cannot be found on electron microscopic examination; transmission of the tumors by filtered extracts has not been successful. In our colonies of Sprague-Dawley rats the incidence of tumors was 22% in fema...