نتایج جستجو برای: decellularization extracellular matrix

تعداد نتایج: 450604  

2015
Chiara Gardin Sara Ricci Letizia Ferroni Riccardo Guazzo Luca Sbricoli Giulia De Benedictis Luca Finotti Maurizio Isola Eriberto Bressan Barbara Zavan Xiaohua Liu

The combination of bone grafting materials with guided bone regeneration (GBR) membranes seems to provide promising results to restore bone defects in dental clinical practice. In the first part of this work, a novel protocol for decellularization and delipidation of bovine bone, based on multiple steps of thermal shock, washes with detergent and dehydration with alcohol, is described. This pro...

Journal: :American journal of stem cells 2014
Francesco Moroni Teodelinda Mirabella

Cardiovascular disease (CVD) is one of the leading causes of death in the Western world. The replacement of damaged vessels and valves has been practiced since the 1950's. Synthetic grafts, usually made of bio-inert materials, are long-lasting and mechanically relevant, but fail when it comes to "biointegration". Decellularized matrices, instead, can be considered biological grafts capable of s...

Journal: :Plastic and reconstructive surgery 2015
Giorgio Giatsidis Erica Dalla Venezia Diego De Stefani Rosario Rizzuto Franco Bassetto

Introduction: Decellularization of tissues provides inductive extra-cellular matrices (ECM) for effective organ reconstruction: this promising approach has not been translated to breast reconstruction yet. 1, 2 We investigated the effectiveness of different decellularization protocols applied to porcine mammary glands with the purpose of developing an inductive biological matrix for prospective...

Journal: :iranian journal of veterinary science and technology 0
amin tavassoli nasser mahdavi-shahri maryam m. matin masoud fereidoni fahimeh shahabipour

extracelllar matrix (ecm) materials from mammalian tissues have been broadly used for tissue engineering for animal models. while decellularization of tissues such as bladder, heart valve, knee meniscus and tendon has been performed, there are a few reports for articular cartilage. in this study we aimed to develop a technique to decellularize bovine articular cartilage as a biological construc...

Journal: :PeerJ 2016
Alexander Golberg Bote G Bruinsma Maria Jaramillo Martin L Yarmush Basak E Uygun

During the past decade, irreversible electroporation (IRE) ablation has emerged as a promising tool for the treatment of multiple diseases including hepatic cancer. However, the mechanisms behind the tissue regeneration following IRE ablation have not been investigated. Our results indicate that IRE treatment immediately kills the cells at the treatment site preserving the extracellular archite...

2013
Clotilde Castaldo Franca Di Meglio Rita Miraglia Anna Maria Sacco Veronica Romano Ciro Bancone Alessandro Della Corte Stefania Montagnani Daria Nurzynska

Cardiac tissue regeneration is guided by stem cells and their microenvironment. It has been recently described that both cardiac stem/primitive cells and extracellular matrix (ECM) change in pathological conditions. This study describes the method for the production of ECM typical of adult human heart in the normal and pathological conditions (ischemic heart disease) and highlights the potentia...

Journal: :Vestnik Transplantologii i Iskusstvennyh Organov 2022

In contrast to decellularization of soft tissues for use as tissue-specific matrices in the creation tissue-engineered constructs, cartilage tissue requires several processing techniques, which can negatively affect biocompatibility and functional properties native extracellular matrix (ECM). Objective: study biocompatible microdispersed 3D from a porcine that is decellularized by sequential ch...

2017
Jeongmin Hwang Boi Hoa San Neill J. Turner Lisa J. White Denver M. Faulk Stephen F. Badylak Yang Li S. Michael Yu

Decellularized extracellular matrix (ECM) derived from tissues and organs are emerging as important scaffold materials for regenerative medicine. Many believe that preservation of the native ECM structure during decellularization is highly desirable. However, because effective techniques to assess the structural damage in ECM are lacking, the disruptive effects of a decellularization method and...

2013
S. Eichhorn D. Baier D. Horst U. Schreiber H. Lahm R. Lange M. Krane

Background. Protocols using chemical reagents for scaffold decellularization can cause changes in the properties of the matrix, depending on the type of tissue and the chemical reagent. Technologies using physical techniques may be possible alternatives for the production grafts with potential superior matrix characteristics. Material and Methods. We tested four different technologies for scaff...

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