نتایج جستجو برای: dectin

تعداد نتایج: 818  

2013
Mohlopheni J. Marakalala David L. Williams Jennifer C. Hoving Rolf Engstad Mihai G. Netea Gordon D. Brown

β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection aga...

Journal: :The EMBO journal 2005
Benjamin N Gantner Randi M Simmons David M Underhill

The ability of Candida albicans to rapidly and reversibly switch between yeast and filamentous morphologies is crucial to pathogenicity, and it is thought that the filamentous morphology provides some advantage during interaction with the mammalian immune system. Dectin-1 is a receptor that binds beta-glucans and is important for macrophage phagocytosis of fungi. The receptor also collaborates ...

Journal: :The New England journal of medicine 2009
Bart Ferwerda Gerben Ferwerda Theo S Plantinga Janet A Willment Annemiek B van Spriel Hanka Venselaar Clara C Elbers Melissa D Johnson Alessandra Cambi Cristal Huysamen Liesbeth Jacobs Trees Jansen Karlijn Verheijen Laury Masthoff Servaas A Morré Gert Vriend David L Williams John R Perfect Leo A B Joosten Cisca Wijmenga Jos W M van der Meer Gosse J Adema Bart Jan Kullberg Gordon D Brown Mihai G Netea

Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1. The mutated form of dectin-1 was poorly expressed, did not mediate beta-glucan binding, and led to...

2006
Yoshiyuki ADACHI

expressed on murine macrophages, dendritic cells, and neutrophils. Murine Dectin-1 (mDectin-1) is involved in the recognition of b-glucan, which is the main component of the fungal cell wall, and induces phagocytosis, the generation of reactive oxygen, and the production of proinflammatory cytokines. Thus, it has become clear that various murine anti-fungal immune responses are mediated by Dect...

2017
Huafeng Wang Taek-Jin Lee Scott J Fites Richard Merkhofer Robert Zarnowski Tristan Brandhorst Kevin Galles Bruce Klein Marcel Wüthrich

The development of vaccines against fungi and other intracellular microbes is impeded in part by a lack of suitable adjuvants. While most current vaccines against infectious diseases preferentially induce production of antibodies, cellular immunity is essential for the resolution of fungal infections. Microbes such as fungi and Mycobacterium tuberculosis require Th17 and Th1 cells for resistanc...

2013
Mohlopheni J. Marakalala Simon Vautier Joanna Potrykus Louise A. Walker Kelly M. Shepardson Alex Hopke Hector M. Mora-Montes Ann Kerrigan Mihai G. Netea Graeme I. Murray Donna M. MacCallum Robert Wheeler Carol A. Munro Neil A. R. Gow Robert A. Cramer Alistair J. P. Brown Gordon D. Brown

The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an essential role in controlling infections with Candida albicans, a normally commensal fungus in man which can cause superficial mucocutaneous infections as well as life-threatening invasive...

Journal: :Veterinary immunology and immunopathology 2009
Jessica R Nerren Michael H Kogut

A critical component of host innate immunity is recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Dectin-1 is the primary PRR for exogenous beta-glucan, a component of fungal and bacterial cell walls. A previous study conducted in our laboratory demonstrated that administration of beta-glucan as a feed additive resulted in increased innate im...

2015
Nan Jiang Guiqiu Zhao Jing Lin Liting Hu Chengye Che Cui Li Qian Wang Qiang Xu Xudong Peng Olaf Kniemeyer

Indoleamine 2,3-dioxygenase (IDO), which is mainly expressed in activated dendritic cells, is known as a regulator of immune responses. However, the role of IDO in immune responses against fungal corneal infection has not been investigated. To evaluate the regulatory mechanisms of IDO in fungal inflammation, we resorted to human corneal epithelial cells (HCECs), known as the first barrier of co...

Journal: :The Journal of Experimental Medicine 2002
Gordon D. Brown Philip R. Taylor Delyth M. Reid Janet A. Willment David L. Williams Luisa Martinez-Pomares Simon Y.C. Wong Siamon Gordon

Zymosan is a beta-glucan- and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and complement receptor 3 (CR3) have historically been considered the major macrophage lectins involved in the nonopsonic recognition of these yeast-derived particles. Using specific carbohydrate inhibito...

2017
Murilo Vieira da Silva Flávia Batista Ferreira França Caroline Martins Mota Arlindo Gomes de Macedo Júnior Eliézer Lucas Pires Ramos Fernanda Maria Santiago José Roberto Mineo Tiago Wilson Patriarca Mineo

Neospora caninum is an intracellular protozoan parasite that has drawn increasing interest due to its association with worldwide repetitive bovine abortions, which cause billionaire losses to the meat and dairy industries annually. Innate immunity plays an important role in infection control, and N. caninum activates the production of inflammatory mediators through toll-like receptors, NOD-like...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید