OBJECTIVE To compare the cytophotometric quantitative expression of Ki-67 cellular proliferation factor in the colloid goiter with papillary carcinoma of the thyroid. METHODS The protein Ki-67 was studied with immunohistochemistry in 20 cases of papillary carcinoma of the thyroid and 12 cases of colloid goiter. The immunomarked cell nuclei were quantified through the software SAMBA 4000 and a...

With fewer than 40 cases described in the otolaryngology literature, mixed medullary papillary thyroid carcinoma represents a rare but phenotypically distinct tumor. While isolated medullary carcinoma may be admixed with normal follicular structures, true mixed carcinoma displays morphological and immunological characteristics of medullary and papillary carcinoma within a single lesion. We repo...

BACKGROUND The evasion of cell death is one of the hallmarks of cancer, contributing to both tumor progression and resistance to therapy. Dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to conventional anticancer treatments and patients with these tumors are difficult to treat. BH3 mimetics are a new class of drugs that target anti-apoptotic prot...

Malignant melanoma can be successfully treated when it is identified in its early stages, but the disease is associated with a poor prognosis when it is detected in an advanced stage. Papillary thyroid carcinoma is a thyroid cancer that has a good prognosis. The present study reports a rare case of malignant melanoma and papillary thyroid carcinoma that were diagnosed concurrently and treated s...

We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (pa...

Background & objective: papillary thyroid cancer is the most common cancer of thyroid accounting for 75%-85% of all thyroid malignancies. Recently, β-catenin has been determined to play a role in clinical course of human epithelial cancers. This study was designed to reveal the association of β-catenin marker and papillary thyroid carcinoma behavior.<b...

The thyroid gland is the largest endocrine in body. Among functions of this gland, we can mention secretion hormones thyroxine (T4) and triiodothyronine (T3), whose release occurs by control stimulating hormone (TSH). Furthermore, it involved calcium metabolism, through calcitonin. Thyroid cancer rare (about 1% all neoplasms), however most frequent among malignant neoplasms. Papillary carcinoma...

BACKGROUND Thyroid nodules with cystic content or mixed sponge-like aspect on ultrasonography and a concordant cytology are strongly predictive of benignity. OBJECTIVES We present 8 patients with honeycomb-like papillary thyroid carcinoma with multiple small cysts on ultrasonography. METHODS The patients were 6 women and 2 men aged between 30 and 57 years. The tumors of these patients showe...

Nuclear grooving; Pseudoinclusion; Thyroid; Papillary Background: Fine Needle Aspiration Cytology is a widely accepted diagnostic tool for thyroid lesions. It is well known that nuclear features form the mainstay of diagnosis for papillary carcinoma thyroid. Focal nuclear features can be missed unless carefully looked for and pose diagnostic difficulty. The aim was to study the cytomorphologica...