Deep Brain Stimulation or DBS is a surgical treatment for Parkinson’s Disease with three stimulation parameters: frequency, pulse width, and voltage. The parameters should be selected appropriately to achieve effective treatment. This selection now, performs clinically. The aim of this research is to study chaotic behavior of recorded tremor of patients under DBS in order to present a computati...

Objective: Post-traumatic stress disorder (PTSD) as one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event. Crocus sativus L., commonly known as saffron have been traditionally used for treatment of stress and anxiety. In this study, we evaluated the effects of peripheral administration of saffron, along with deep brain stimulation (DBS) in a post-trauma...

Deep brain stimulation (DBS) is regarded as a feasible Parkinson’s disease (PD) treatment option. The subthalamic nucleus (STN) and globus pallidus (GPi) are the two most common sites for DBS. following criteria were used to select studies that examined Unified PD Rating Scale (UPDRS) III: (1) had at least three months of follow-up; (2) compared both GPi STN-DBS; (3) each group included five in...

PURPOSE Treatment-resistant cluster headache can be successfully alleviated with deep brain stimulation (DBS) of the posterior hypothalamus [1]. Magnetoencephalography (MEG) is a non-invasive functional imaging technique with both high temporal and high spatial resolution. However, it is not known whether the inherent electromagnetic (EM) noise produced by high frequency DBS is compatible with ...

Deep brain stimulation (DBS) of the basal ganglia is an effective treatment for select movement disorders, including Parkinson's disease, essential tremor and dystonia. Based on these successes, DBS has been explored as an experimental treatment for medication-resistant neuropsychiatric disease. During a multiyear experience employing DBS to treat patients for obsessive compulsive disorder (OCD...

Multiple studies have shown bilateral improvement in motor symptoms in Parkinson disease (PD) following unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal segment of the globus pallidus, yet the mechanism(s) underlying this phenomenon are poorly understood. We hypothesized that STN neuronal activity is altered by contralateral STN DBS. This hypothesis was test...

Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective surgical treatment for Parkinson’s disease (PD), alleviating motor symptoms and restoring patients’ quality life. Research into long-term effects DBS on human lacking. This study aims to investigate neuroanatomical neurochemical alterations induced by chronic stimulations STN, correlate these changes with cli...

In the more than 30 years that have passed since its introduction, deep brain stimulation (DBS) has been shown to be effective and safe for a growing number of diseases, such as depression obsessive-compulsive disorder, well movement disorders Parkinson’s disease, dystonia, essential tremor. As result population aging due increase in life expectancy, patients requiring DBS implantation is incre...

BACKGROUND Chronic deep brain stimulation (DBS) of the globus pallidus internus (GPi) has become an established treatment for dystonia. While bradykinetic symptoms may occur on chronic stimulation, the appearance of hyperkinetic movements has not been well characterized. CASE REPORT We report on the development of hyperkinesias after more than 10 years of GPi DBS. DISCUSSION Hyperkinesias m...

In Diagnostic and Statistical Manual (DSM)-5, catatonia is defined by the presence of three or more of 12 psychomotor disturbances, which may be associated with mental disorder or medical condition (Tandon et al. 2013). Catatonia could be treated with benzodiazepine (BZD) or electroconvulsive therapy (ECT) (Lin & Huang 2013, Huang et al. 2013, Raveendranathan et al. 2012). Parkinson's disease (...